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“代谢健康型”肥胖与“标准型”肥胖的子宫内膜癌患者特征：代谢健康型肥胖的发生率下降

Features of endometrial cancer in patients with 'metabolically healthy' versus 'standard' obesity: the decreasing frequency of metabolically healthy obesity.

作者信息

Berstein Lev M, Poroshina Tatyana E, Turkevich Elena A, Vasilyev Dmitry A, Baltrukova Alexandra N, Kovalenko Irina M, Berlev Igor V

机构信息

Laboratory of Oncoendocrinology, N.N. Petrov Research Institute of Oncology, St Petersburg 197758, Russia; Laboratory of Oncoendocrinology, N.N. Petrov Research Institute of Oncology, St Petersburg 197758, Russia.

Department of Tumor Morphology, N.N. Petrov Research Institute of Oncology, St Petersburg 197758, Russia; Department of Tumor Morphology, N.N. Petrov Research Institute of Oncology, St Petersburg 197758, Russia.

出版信息

Future Sci OA. 2015 Nov 1;1(4):FSO68. doi: 10.4155/fso.15.68. eCollection 2015 Nov.

DOI:10.4155/fso.15.68
PMID:28031919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5137934/
Abstract

BACKGROUND

As endometrial cancer (EC) prevalence increases with obesity, we aimed to determine whether EC characteristics depend upon obesity type: 'standard' (SO) or 'metabolically healthy obesity' (MHO).

PATIENTS & METHODS: 258 EC patients were included. Data on anthropometry, blood hormones, lipids and glucose, and tumor features were collected.

RESULTS

EC clinicopathologic characteristics and clinical stage correlate differently with BMI and obesity type. BMI is related inversely with tumor grade while SO patients are characterized by a more advanced clinical stage than those with MHO. Besides typical insulin resistance signs, EC patients with SO often display a higher serum leptin/adiponectin ratio compared with MHO patients. Historical data suggest a gradual increase in EC patient height and weight, and a decrease in MHO prevalence.

CONCLUSION

It is currently unknown whether the latter observation reflects the evolution of EC, or obesity alongside the current epidemic. Regardless, the reduced MHO prevalence demonstrates the need for more intensive preventive measures aimed at obesity and obesity-associated conditions, including different EC subtypes.

摘要

背景

随着子宫内膜癌（EC）的患病率随肥胖增加，我们旨在确定EC的特征是否取决于肥胖类型：“标准型”（SO）或“代谢健康型肥胖”（MHO）。

患者与方法

纳入258例EC患者。收集人体测量学、血液激素、脂质和葡萄糖以及肿瘤特征的数据。

结果

EC的临床病理特征和临床分期与BMI和肥胖类型的相关性不同。BMI与肿瘤分级呈负相关，而SO患者的临床分期比MHO患者更晚。除了典型的胰岛素抵抗迹象外，与MHO患者相比，SO的EC患者通常表现出更高的血清瘦素/脂联素比值。历史数据表明，EC患者的身高和体重逐渐增加，而MHO患病率下降。

结论

目前尚不清楚后一种观察结果是反映了EC的演变，还是肥胖以及当前的流行情况。无论如何，MHO患病率的降低表明需要针对肥胖和肥胖相关疾病，包括不同的EC亚型，采取更强化的预防措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5137934/aa8a7581a5a4/fso-01-68-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5137934/72235ce4d01b/fso-01-68-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5137934/aa8a7581a5a4/fso-01-68-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5137934/72235ce4d01b/fso-01-68-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f4d/5137934/aa8a7581a5a4/fso-01-68-g2.jpg

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