Velázquez-Fernández David, Mercado-Celis Gabriela, Flores-Morales Jeny, Clavellina-Gaytán Diana, Vidrio Ramón, Vidrio Eduardo, Mosti Maureen, Sánchez-Aguilar Hugo, Rodriguez Donaji, León Pablo, Herrera Miguel F
The American British Cowdray (ABC) Medical Center, Center for Nutrition, Obesity and Metabolic Alterations (CNOAM), Mexico City, Mexico.
Departamento de Cirugía, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Tlalpan, Belisario Domínguez Sección XVI, CP 14080, Ciudad de Mexico, Mexico.
Obes Surg. 2017 Jun;27(6):1481-1492. doi: 10.1007/s11695-016-2501-9.
Obesity is the result of a complex interaction between multiple genetic traits and psychological, behavioral, nutritional and environmental factors.
The aims of the study were (a) to comparatively evaluate the presence of 20 candidate gene single nucleotide polymorphisms (SNPs) in morbidly obese patients, (2) their association to comorbid conditions and (3) their impact on weight loss after a Roux-en-Y gastric bypass (RYGB).
Two hundred forty-nine patients were eligible for this study. Clinical, anthropometric, biochemical and demographic variables were analyzed. Body mass index (BMI) and composition were assessed by bioelectrical impedance. Twenty SNPs were included for analysis.
There were 168 Mexican mestizos (67.5 %) and 81 (32.5 %) patients with other ancestral origin. One hundred fifty-nine (64.1 %) were females. Mean ± SD age of the general cohort was 41.1 ± 11.3 years (17-71). Preoperative mean ± SD BMI was 42.5 ± 6.5 kg/m. There were no significant differences between mestizo and non-mestizo for most SNPs except for IFI, LIPC, and ST8SIA2. FTO (OR = 1.71; CI = 1.14-2.57; p = 0.008) and APOB (OR = 0.31; CI = 0.14-0.72; p = 0.004) result is statistically associated to high blood pressure and FTO (OR = 2.0; CI = 1.3-3.1; p = 0.001), GNB3 (OR = 2.69; CI = 1.0-7.2; p = 0.04), IFI30 (OR = 2.0; CI = 1.16-3.6; p = 0.01), and MC4R (OR = 1.81; CI = 1.13-2.9; p = 0.01) to type 2 diabetes (T2D). Based on ANOVA analysis, POMC (rs1042571) was the SNP most significantly associated to a higher weight loss after RYGB.
Obese patients have similar SNP frequencies. Several SNP results are statistically associated to high blood pressure and T2D. POMC was significantly associated to a higher surgically induced weight loss.
肥胖是多种遗传特征与心理、行为、营养和环境因素之间复杂相互作用的结果。
本研究的目的是：（a）比较评估病态肥胖患者中20个候选基因单核苷酸多态性（SNP）的存在情况；（2）它们与合并症的关联；（3）它们对Roux-en-Y胃旁路术（RYGB）后体重减轻的影响。
249名患者符合本研究条件。分析了临床、人体测量、生化和人口统计学变量。通过生物电阻抗评估体重指数（BMI）和身体成分。纳入20个SNP进行分析。
有168名墨西哥混血儿（67.5%）和81名（32.5%）其他祖籍的患者。159名（64.1%）为女性。整个队列的平均年龄±标准差为41.1±11.3岁（17 - 71岁）。术前平均BMI±标准差为42.5±6.5kg/m²。除IFI、LIPC和ST8SIA2外，大多数SNP在混血儿和非混血儿之间无显著差异。FTO（OR = 1.71；CI = 1.14 - 2.57；p = 0.008）和APOB（OR = 0.31；CI = 0.14 - 0.72；p = 0.004）的结果与高血压在统计学上相关，FTO（OR = 2.0；CI = 1.3 - 3.1；p = 0.001）、GNB3（OR =
