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锶和锌共掺杂介孔生物活性玻璃纳米颗粒在骨组织工程应用中的潜在用途

Strontium and Zinc Co-Doped Mesoporous Bioactive Glass Nanoparticles for Potential Use in Bone Tissue Engineering Applications.

作者信息

Naruphontjirakul Parichart, Li Meng, Boccaccini Aldo R

机构信息

Biological Engineering Program, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand.

Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany.

出版信息

Nanomaterials (Basel). 2024 Mar 26;14(7):575. doi: 10.3390/nano14070575.

DOI:10.3390/nano14070575
PMID:38607110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11013354/
Abstract

Mesoporous bioactive glass nanoparticles (MBGNs) have attracted significant attention as multifunctional nanocarriers for various applications in both hard and soft tissue engineering. In this study, multifunctional strontium (Sr)- and zinc (Zn)-containing MBGNs were successfully synthesized via the microemulsion-assisted sol-gel method combined with a cationic surfactant (cetyltrimethylammonium bromide, CTAB). Sr-MBGNs, Zn-MBGNs, and Sr-Zn-MBGNs exhibited spherical shapes in the nanoscale range of 100 ± 20 nm with a mesoporous structure. Sr and Zn were co-substituted in MBGNs (60SiO-40CaO) to induce osteogenic potential and antibacterial properties without altering their size, morphology, negative surface charge, amorphous nature, mesoporous structure, and pore size. The synthesized MBGNs facilitated bioactivity by promoting the formation of an apatite-like layer on the surface of the particles after immersion in Simulated Body Fluid (SBF). The effect of the particles on the metabolic activity of human mesenchymal stem cells was concentration-dependent. The hMSCs exposed to Sr-MBGNs, Zn-MBGNs, and Sr-Zn-MBGNs at 200 μg/mL enhanced calcium deposition and osteogenic differentiation without osteogenic supplements. Moreover, the cellular uptake and internalization of Sr-MBGNs, Zn-MBGNs, and Sr-Zn-MBGNs in hMSCs were observed. These novel particles, which exhibited multiple functionalities, including promoting bone regeneration, delivering therapeutic ions intracellularly, and inhibiting the growth of and , are potential nanocarriers for bone regeneration applications.

摘要

介孔生物活性玻璃纳米颗粒（MBGNs）作为多功能纳米载体在硬组织和软组织工程的各种应用中引起了广泛关注。在本研究中，通过微乳液辅助溶胶 - 凝胶法结合阳离子表面活性剂（十六烷基三甲基溴化铵，CTAB）成功合成了含锶（Sr）和锌（Zn）的多功能MBGNs。Sr-MBGNs、Zn-MBGNs和Sr-Zn-MBGNs在100±20nm的纳米尺度范围内呈现球形，具有介孔结构。Sr和Zn在MBGNs（60SiO-40CaO）中共取代，以诱导成骨潜力和抗菌性能，而不改变其尺寸、形态、表面负电荷、无定形性质、介孔结构和孔径。合成的MBGNs在浸入模拟体液（SBF）后通过促进颗粒表面形成类磷灰石层来促进生物活性。颗粒对人间充质干细胞代谢活性的影响呈浓度依赖性。在无成骨补充剂的情况下，暴露于200μg/mL的Sr-MBGNs、Zn-MBGNs和Sr-Zn-MBGNs的人间充质干细胞增强了钙沉积和成骨分化。此外，观察到Sr-MBGNs、Zn-MBGNs和Sr-Zn-MBGNs在人间充质干细胞中的细胞摄取和内化。这些具有多种功能的新型颗粒，包括促进骨再生、在细胞内递送治疗性离子以及抑制[具体细菌名称缺失]的生长，是骨再生应用的潜在纳米载体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/6c5318117091/nanomaterials-14-00575-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/dca059a5d7a6/nanomaterials-14-00575-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/ecc6e72771db/nanomaterials-14-00575-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/f733c0bc7aeb/nanomaterials-14-00575-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/806f88b30b43/nanomaterials-14-00575-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/48f81e1722bf/nanomaterials-14-00575-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/10b09b7076fa/nanomaterials-14-00575-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/d87d90b6f16d/nanomaterials-14-00575-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/34772bf04797/nanomaterials-14-00575-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/dd1ab16ed23c/nanomaterials-14-00575-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/906bcb9901c7/nanomaterials-14-00575-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/6c5318117091/nanomaterials-14-00575-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/dca059a5d7a6/nanomaterials-14-00575-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/ecc6e72771db/nanomaterials-14-00575-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/f733c0bc7aeb/nanomaterials-14-00575-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/806f88b30b43/nanomaterials-14-00575-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/48f81e1722bf/nanomaterials-14-00575-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/10b09b7076fa/nanomaterials-14-00575-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/d87d90b6f16d/nanomaterials-14-00575-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/34772bf04797/nanomaterials-14-00575-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/dd1ab16ed23c/nanomaterials-14-00575-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/906bcb9901c7/nanomaterials-14-00575-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9529/11013354/6c5318117091/nanomaterials-14-00575-g011.jpg

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引用本文的文献

[1]
Strategic incorporation of metal ions in bone regenerative scaffolds: multifunctional platforms for advancing osteogenesis.

Regen Biomater. 2025-7-2

[2]
Enhanced functionalities of biomaterials through metal ion surface modification.

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[3]
Advances in Zinc-Containing Bioactive Glasses: A Comprehensive Review.

J Funct Biomater. 2024-9-8

本文引用的文献

[1]
Correlating the Effect of Composition and Textural Properties on Bioactivity for Pristine and Copper-Doped Binary Mesoporous Bioactive Glass Nanoparticles.

Materials (Basel). 2023-10-14

[2]
Multifunctional Zn and Ag co-doped bioactive glass nanoparticles for bone therapeutic and regeneration.

Sci Rep. 2023-4-25

[3]
Cellular Uptake of Modified Mesoporous Bioactive Glass Nanoparticles for Effective Intracellular Delivery of Therapeutic Agents.

Int J Nanomedicine. 2023

[4]
The Role of Zinc in Bone Tissue Health and Regeneration-a Review.

Biol Trace Elem Res. 2023-12

[5]
Hydroxyapatite or Fluorapatite-Which Bioceramic Is Better as a Base for the Production of Bone Scaffold?-A Comprehensive Comparative Study.

Int J Mol Sci. 2023-3-14

[6]
Facile post modification synthesis of copper-doped mesoporous bioactive glass with high antibacterial performance to fight bone infection.

Biomater Adv. 2023-1

[7]
Mesoporous Bioactive Glass Nanoparticles in the SiO-PO-CaO-MO (M=Mg, Zn) System: Synthesis and Properties.

J Funct Biomater. 2022-10-7

[8]
Nanomaterial-Based Zinc Ion Interference Therapy to Combat Bacterial Infections.

Front Immunol. 2022

[9]
Zinc-Containing Sol-Gel Glass Nanoparticles to Deliver Therapeutic Ions.

Nanomaterials (Basel). 2022-5-16

[10]
Mesoporous bioactive glass nanoparticles doped with magnesium: drug delivery and acellular bioactivity.

RSC Adv. 2019-4-17

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