Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
School of Molecular Sciences and Center of Molecular Design & Biomimetics at Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.
Angew Chem Int Ed Engl. 2017 Feb 1;56(6):1586-1589. doi: 10.1002/anie.201610133. Epub 2016 Dec 30.
We describe the use of a frame-guided assembly (FGA) strategy to construct cuboid and dumbbell-shaped hetero-vesicles on DNA origami nanostructure scaffolds. These are achieved by varying the design of the DNA origami scaffolds that direct the distribution of the leading hydrophobic groups (LHG). By careful selection of LHGs, different types of amphiphiles (both polymer and small-molecule surfactants) were guided to form hetero-vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero-vesicle assemblies with complex DNA nano-scaffolds.
我们描述了一种框架引导组装（FGA）策略，用于在 DNA 折纸纳米结构支架上构建长方体和哑铃形的杂化囊泡。这是通过改变 DNA 折纸支架的设计来实现的，该设计指导了疏水性基团（LHG）的分布。通过仔细选择 LHG，可以引导不同类型的两亲物（聚合物和小分子表面活性剂）形成杂化囊泡，证明了 FGA 策略的多功能性及其构建具有复杂 DNA 纳米支架的不对称和动态杂化囊泡组装体的潜力。
