Torres Kátia Andrea de Menezes, Lima Sônia Maria Rolim Rosa, Ueda Suely Mitoi Ykko
Santa Casa de Sao Paulo School of Medical Sciences, São Paulo, SP, Brazil.
Department of Gynecology and Obstetrics, School of Medical Sciences, Santa Casa de São Paulo, São Paulo, SP, Brazil.
Rev Bras Ginecol Obstet. 2016 Dec;38(12):593-599. doi: 10.1055/s-0036-1597694. Epub 2016 Dec 30.
To evaluate the antifungal susceptibility profile of the aqueous extract of the bark of Raddi against the strains of the genus . By using the disk diffusion method, 50 samples of the genus (; ; ; and ), isolated from patients receiving treatment at Hospital Santa Casa de Misericórdia de São Paulo, and 1 American Type Culture Collection (ATCC) sample of each species were tested against: the isolated aqueous extract of the bark of Raddi, isolated nystatin, and the association of nystatin and the aqueous extract of Raddi. There were no significant differences regarding the different strains of tested. In the presence of the aqueous extract of Raddi, no inhibition halo was visible. Isolated nystatin formed an inhibition halo measuring respectively 18.50 mm and 19.50 mm for the species and the others referred to as non- (; ; and ). The association of nystatin and the aqueous extract of Raddi resulted in inhibition halos measuring 14.25 mm and 16.50 mm respectively. The comparisons of these results are statistically significant (< 0,001). The aqueous extract of Raddi showed no antifungal activity in vitro against the strains tested, whereas the association of nystatin and the aqueous extract of Raddi caused a decrease in the inhibition halo when compared with isolated nystatin.
评估拉迪树皮水提取物对该属菌株的抗真菌药敏谱。通过纸片扩散法，对从圣保罗圣卡塔琳娜慈善医院接受治疗的患者中分离出的50份该属样本（；；；和）以及每个物种的1份美国典型培养物保藏中心（ATCC）样本进行了测试，测试对象包括：拉迪树皮分离出的水提取物、分离出的制霉菌素以及制霉菌素与拉迪树皮水提取物的组合。在所测试的不同菌株之间没有显著差异。在有拉迪树皮水提取物存在的情况下，未观察到抑菌圈。分离出的制霉菌素对物种形成的抑菌圈分别为18.50毫米和19.50毫米，对其他被称为非（；；和）的物种形成的抑菌圈分别为18.50毫米和19.50毫米。制霉菌素与拉迪树皮水提取物的组合产生的抑菌圈分别为14.25毫米和16.50毫米。这些结果的比较具有统计学意义（<0.001）。拉迪树皮水提取物在体外对所测试的菌株没有抗真菌活性，而与分离出的制霉菌素相比，制霉菌素与拉迪树皮水提取物的组合导致抑菌圈减小。
