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探寻精神病表达背后的环境机制：引言

The Search for Environmental Mechanisms Underlying the Expression of Psychosis: Introduction.

作者信息

van Os Jim, Reininghaus Ulrich, Meyer-Lindenberg Andreas

机构信息

Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.

Psychosis Studies Department, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK.

出版信息

Schizophr Bull. 2017 Mar;43(2):283-286. doi: 10.1093/schbul/sbw178. Epub 2016 Dec 29.

DOI:10.1093/schbul/sbw178
PMID:28039422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5782498/
Abstract

In this themed issue, a number of articles are presented that investigate environmental mechanisms in psychotic disorder. Below, we describe some of the challenges associated with this research, in terms of phenotypic definition, the nature of environmental impact and associated design and measurement issues.

摘要

在本期主题特刊中，发表了多篇探讨精神障碍环境机制的文章。以下，我们将从表型定义、环境影响的性质以及相关的设计和测量问题等方面，描述这项研究面临的一些挑战。

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2
Childhood adversity and psychosis: a systematic review of bio-psycho-social mediators and moderators.儿童逆境与精神病：生物-心理-社会中介和调节因素的系统综述。
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Med J Aust. 2019 Nov;211 Suppl 9:S3-S46. doi: 10.5694/mja2.50383.
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[Post-traumatic stress disorder in reaction to psychotic experience: A systematic revue].[对精神病性体验的反应性创伤后应激障碍：一项系统综述]
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Does normal developmental expression of psychosis combine with environmental risk to cause persistence of psychosis? A psychosis proneness-persistence model.精神病的正常发育性表达与环境风险相结合会导致精神病持续存在吗？一种精神病易感性-持续性模型。
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引用本文的文献

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A comparison of neighbourhood level variation and risk factors for affective versus non-affective psychosis.比较社区水平的变异和情感性与非情感性精神病的风险因素。
Schizophr Res. 2023 Jun;256:126-132. doi: 10.1016/j.schres.2022.05.015. Epub 2022 Jun 11.
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Latent state-trait structure of BPRS subscales in clinical high-risk state and first episode psychosis.BPRS 分量表在临床高风险状态和首发精神病中的潜在状态-特质结构。
Sci Rep. 2022 Apr 22;12(1):6652. doi: 10.1038/s41598-022-10207-x.
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The Self and Its Nature: A Psychopathological Perspective on the Risk-Reducing Effects of Environmental Green Space for Psychosis.自我及其本质：从精神病理学角度看环境绿地对精神病的风险降低作用
Front Psychol. 2020 Nov 11;11:531840. doi: 10.3389/fpsyg.2020.531840. eCollection 2020.
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Interaction of both positive and negative daily-life experiences with haplotype on psychosis risk.积极和消极的日常生活经历与精神分裂症风险单倍型的相互作用。
Eur Psychiatry. 2020 Feb 7;63(1):e11. doi: 10.1192/j.eurpsy.2019.4.

本文引用的文献

1
Modeling the Interplay Between Psychological Processes and Adverse, Stressful Contexts and Experiences in Pathways to Psychosis: An Experience Sampling Study.精神分裂症发生发展的心理过程与不良压力性环境及体验的相互作用关系的建模：一项经验抽样研究。
Schizophr Bull. 2017 Mar 1;43(2):302-315. doi: 10.1093/schbul/sbw185.
2
Evidence That the Urban Environment Moderates the Level of Familial Clustering of Positive Psychotic Symptoms.证据表明，城市环境调节了阳性精神病症状的家庭聚集程度。
Schizophr Bull. 2017 Mar 1;43(2):325-331. doi: 10.1093/schbul/sbw186.
3
Evidence That the Impact of Childhood Trauma on IQ Is Substantial in Controls, Moderate in Siblings, and Absent in Patients With Psychotic Disorder.有证据表明，童年创伤对智商的影响在对照组中很大，在兄弟姐妹中中等，而在精神障碍患者中不存在。
Schizophr Bull. 2017 Mar 1;43(2):316-324. doi: 10.1093/schbul/sbw177.
4
Elevated Striatal Dopamine Function in Immigrants and Their Children: A Risk Mechanism for Psychosis.移民及其子女纹状体多巴胺功能增强：一种精神病的风险机制。
Schizophr Bull. 2017 Mar 1;43(2):293-301. doi: 10.1093/schbul/sbw181.
5
Biological Mechanisms Whereby Social Exclusion May Contribute to the Etiology of Psychosis: A Narrative Review.社会排斥可能导致精神病病因的生物学机制：一项叙述性综述。
Schizophr Bull. 2017 Mar;43(2):287-292. doi: 10.1093/schbul/sbw180. Epub 2017 Jan 3.
6
Aberrant activity and connectivity of the posterior superior temporal sulcus during social cognition in schizophrenia.精神分裂症患者社会认知过程中后上颞叶回异常活动和连通性。
Eur Arch Psychiatry Clin Neurosci. 2017 Oct;267(7):597-610. doi: 10.1007/s00406-016-0737-y. Epub 2016 Oct 21.
7
The social defeat hypothesis of schizophrenia: issues of measurement and reverse causality.精神分裂症的社会挫败假说：测量问题与反向因果关系
World Psychiatry. 2016 Oct;15(3):294-295. doi: 10.1002/wps.20369.
8
Specificity, reliability and sensitivity of social brain responses during spontaneous mentalizing.自发心理化过程中社会脑反应的特异性、可靠性和敏感性。
Soc Cogn Affect Neurosci. 2016 Nov;11(11):1687-1697. doi: 10.1093/scan/nsw098. Epub 2016 Jul 21.
9
Psychosis as a transdiagnostic and extended phenotype in the general population.精神病作为普通人群中的一种跨诊断和扩展表型。
World Psychiatry. 2016 Jun;15(2):118-24. doi: 10.1002/wps.20310.
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Meta-analysis of the Association Between the Level of Cannabis Use and Risk of Psychosis.大麻使用水平与精神病风险之间关联的荟萃分析。
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