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通过铱催化的碳-碳键形成转移氢化对含有全碳季碳立体中心的氧杂环丁烷进行对映选择性合成。

Enantioselective Synthesis of Oxetanes Bearing All-Carbon Quaternary Stereocenters via Iridium-Catalyzed C-C Bond-Forming Transfer Hydrogenation.

作者信息

Guo Yi-An, Lee Wonchul, Krische Michael J

机构信息

University of Texas at Austin, Department of Chemistry, 1 University Station-A5300, Austin, TX, 78712-1167, USA.

出版信息

Chemistry. 2017 Feb 21;23(11):2557-2559. doi: 10.1002/chem.201606046. Epub 2017 Jan 27.

DOI:10.1002/chem.201606046
PMID:28039892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5391976/
Abstract

Oxetanes bearing all-carbon quaternary stereocenters are readily prepared through the iridium-catalyzed anti-diastereo- and enantioselective C-C coupling of primary alcohols and isoprene oxide. Based on this methodology, an oxetane containing analogue of haloperidol was prepared. A related azetidine formation is also described.

摘要

通过铱催化的伯醇与环氧异戊二烯的非对映选择性和对映选择性碳-碳偶联反应，可以轻松制备含有全碳季立体中心的氧杂环丁烷。基于此方法，制备了一种含有氟哌啶醇类似物的氧杂环丁烷。还描述了一种相关的氮杂环丁烷的形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3909/5391976/c074e529fa03/nihms856618f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3909/5391976/4c65a28b2379/nihms856618f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3909/5391976/440c7e6999a3/nihms856618f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3909/5391976/c074e529fa03/nihms856618f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3909/5391976/4c65a28b2379/nihms856618f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3909/5391976/440c7e6999a3/nihms856618f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3909/5391976/c074e529fa03/nihms856618f3.jpg

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