School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Department of Dermatology, Johns Hopkins University, Baltimore, Maryland.
J Am Acad Dermatol. 2017 May;76(5):979-989. doi: 10.1016/j.jaad.2016.10.032. Epub 2016 Dec 29.
Hidradenitis suppurativa is a debilitating inflammatory skin disease with a chronic course and often disappointing response to treatment. Though a minority of persons (20%) reports symptom remission during pregnancy, the vast majority experiences no relief (72%), and few experience clinical deterioration (8%). Disease flares are also observed post-partum. The pathophysiological basis for pregnancy-associated fluctuations in clinical status is currently unknown. Because most women with HS require ongoing management throughout pregnancy, it is important to evaluate the suitability and safety of current treatment options for pregnant women. The following review will outline current management strategies for HS and their compatibility with pregnancy and lactation.
化脓性汗腺炎是一种使人虚弱的炎症性皮肤病,具有慢性病程,且对治疗的反应往往不佳。尽管少数患者(20%)报告在怀孕期间症状缓解,但绝大多数患者没有缓解(72%),少数患者(8%)出现临床恶化。产后也会出现疾病发作。目前尚不清楚导致妊娠期临床状况波动的病理生理基础。由于大多数患有化脓性汗腺炎的女性在整个怀孕期间都需要持续管理,因此评估当前治疗选择对孕妇的适用性和安全性非常重要。以下综述将概述化脓性汗腺炎的当前治疗策略及其与妊娠和哺乳期的兼容性。