Wang Z-L, Zou L, Lu Z-W, Xie X-Q, Jia Z-Z, Pan C-J, Zhang G-X, Ge X-M
Department of Radiology, Shanghai General Hospital of Nanjing Medical University, NO.100 Haining Road, Shanghai 200080, China; Department of Radiology, The First Affiliated Hospital of Soochow University, No.188, Shizi Road, Suzhou 215006, China.
Department of Radiology, Changzhou Second People's Hospital, Nanjing Medical University, No.29 Xinglong Road, Changzhou 213003, China.
Clin Radiol. 2017 Apr;72(4):340.e1-340.e7. doi: 10.1016/j.crad.2016.11.012. Epub 2016 Dec 29.
To explore the altered spontaneous cerebral activity patterns and impaired functional regions in patients with diabetic retinopathy (DR) using resting-state functional magnetic resonance imaging (rs-fMRI) based on the amplitude of low-frequency fluctuations (ALFF) algorithm.
Twenty-one patients with DR (mean age, 54.9±9.9 years; 11 females) and 17 healthy control subjects (54.8±5.7 years; 9 females) were prospectively studied. The DR patients underwent laboratory tests. All individuals underwent a neuropsychological test. The differences in the ALFF values between the two groups were compared. The relationships between ALFF values and clinical measurements were analysed using a multiple-factor analysis.
Compared to the controls, the DR group showed significantly increased ALFF values in the bilateral occipital gyrus, right lingual gyrus, and precuneus, and decreased values in the right posterior/anterior cerebellar lobe and the parahippocampal, fusiform, superior temporal, inferior parietal, and angular gyrus. Furthermore, the Montreal Cognitive Assessment (MoCA) scores were negatively correlated with decreased ALFF values in the right occipital lobe of the DR group, while increased ALFF values in the right precuneus and lingual gyrus were found to be positively correlated with glycosylated haemoglobin (HbA1c) levels.
Patients with DR showed spontaneous cerebral activity abnormalities in many cerebral regions that were associated with cognitive impairments. HbA1c levels altered spontaneous cerebral activity in DR patients.
基于低频振幅（ALFF）算法，运用静息态功能磁共振成像（rs-fMRI）探索糖尿病视网膜病变（DR）患者大脑自发活动模式的改变及功能受损区域。
前瞻性研究21例DR患者（平均年龄54.9±9.9岁；女性11例）和17名健康对照者（54.8±5.7岁；女性9例）。DR患者接受实验室检查。所有个体均接受神经心理学测试。比较两组间ALFF值的差异。采用多因素分析方法分析ALFF值与临床测量指标之间的关系。
与对照组相比，DR组双侧枕叶、右侧舌回和楔前叶的ALFF值显著升高，而右侧小脑后/前叶以及海马旁回、梭状回、颞上回、顶下小叶和角回的ALFF值降低。此外，DR组右侧枕叶ALFF值降低与蒙特利尔认知评估（MoCA）评分呈负相关，而右侧楔前叶和舌回ALFF值升高与糖化血红蛋白（HbA1c）水平呈正相关。
DR患者在多个脑区存在大脑自发活动异常，且与认知障碍相关。HbA1c水平改变了DR患者的大脑自发活动。
