State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Rd, Shanghai, 200032, China.
Angew Chem Int Ed Engl. 2017 Feb 1;56(6):1614-1618. doi: 10.1002/anie.201611007. Epub 2017 Jan 2.
A unique Ir complex ( NC P)Ir with the pyridine-phosphine pincer as the sole ligand, featuring a dual agostic interaction between the Ir and two σ C-H bonds from a tBu substituent, has been prepared. This complex exhibits exceptionally high activity and excellent regio- and stereoselectivity for monoisomerization of 1-alkenes to trans-2-alkenes with wide functional-group tolerance. Reactions can be performed in neat reactant on a more than 100 gram scale using 0.005 mol % catalyst loadings with turnover numbers up to 19000.
已制备出一种独特的 Ir 配合物（NC P）Ir，其唯一配体为吡啶-膦钳形配体，Ir 与叔丁基上的两个 σ C-H 键之间存在双重超共轭相互作用。该配合物对 1-烯烃异构化为反式 2-烯烃具有极高的活性和优异的区域和立体选择性，并且对官能团具有广泛的耐受性。反应可以在反应物中进行，在 100 克以上的规模下，使用 0.005 mol%的催化剂负载量，反应数高达 19000。
