Jaakkonen A, Salmenlinna S, Rimhanen-Finne R, Lundström H, Heinikainen S, Hakkinen M, Hallanvuo S
Finnish Food Safety Authority Evira, Helsinki, Finland.
National Institute for Health and Welfare (THL), Helsinki, Finland.
Zoonoses Public Health. 2017 Sep;64(6):468-475. doi: 10.1111/zph.12327. Epub 2017 Jan 3.
Shiga toxin-producing, sorbitol-fermenting Escherichia coli O157 (SF O157) has emerged as a cause of severe human illness. Despite frequent human findings, its transmission routes and reservoirs remain largely unknown. Foodborne transmission and reservoir in cattle have been suspected, but with limited supporting evidence. This study describes the outbreak of SF O157 that occurred in Finland in 2012. The outbreak originated from a recreational farm selling unpasteurized milk, as revealed by epidemiologic and microbiological investigations, and involved six hospitalized children and two asymptomatic adults with culture-confirmed infection. An identical strain of SF O157 was isolated from patients, cattle and the farm environment, and epidemiologic analysis suggested unpasteurized milk as the vehicle of transmission. This study reports the first milkborne outbreak of SF O157, provides supporting evidence of cattle as a reservoir and highlights the health risks related to the consumption of unpasteurized milk.
产志贺毒素、能发酵山梨醇的大肠杆菌O157（SF O157）已成为导致人类严重疾病的病因。尽管在人类中经常发现它，但它的传播途径和宿主仍大多未知。虽然怀疑食源性传播以及牛是其宿主，但支持证据有限。本研究描述了2012年在芬兰发生的SF O157疫情。流行病学和微生物学调查显示，此次疫情起源于一家出售未经巴氏杀菌牛奶的休闲农场，涉及6名住院儿童和2名无症状成人，他们的感染经培养确诊。从患者、牛和农场环境中分离出了相同菌株的SF O157，流行病学分析表明未经巴氏杀菌的牛奶是传播媒介。本研究报告了首例由牛奶传播的SF O157疫情，提供了牛作为宿主的支持证据，并突出了饮用未经巴氏杀菌牛奶相关的健康风险。
