Public Health England South East, Hampshire and Isle of Wight Health Protection Team, Fareham, United Kingdom.
National Infection Service, Public Health England, London, United Kingdom.
Euro Surveill. 2019 Apr;24(16). doi: 10.2807/1560-7917.ES.2019.24.16.1800191.
An outbreak of Shiga toxin-producing (STEC) O157:H7 occurred on the Isle of Wight between August and October 2017. Of the seven cases linked to the outbreak, five were identified through the statutory notification process and two were identified through national surveillance of whole genome sequencing data. Enhanced surveillance questionnaires established a common link to a farm, and link to the likely food vehicle, raw drinking milk (RDM). Microbiological investigations, including PCR, identified the presence of STEC O157:H7 in samples of RDM. Analysis of core genome single nucleotide polymorphism (SNP) data of STEC O157:H7 from human stool specimens, animal faecal samples and RDM demonstrated a one SNP difference between isolates, and therefore close genetic relatedness. Control measures that were put in place included suspension of sales and recall of RDM, as well as restrictions on public access to parts of the farm. Successful integration of traditional epidemiological surveillance and advanced laboratory methods for the detection and characterisation of STEC O157:H7 from human, animal and environmental samples enabled prompt identification of the outbreak vehicle and provided evidence to support the outbreak control team's decision-making, leading to implementation of effective control measures in a timely manner.
2017 年 8 月至 10 月，怀特岛爆发了产志贺毒素的（STEC）O157:H7 疫情。在与疫情相关的七例病例中，五例是通过法定通知程序确定的，两例是通过对全基因组测序数据的国家监测确定的。强化监测问卷确定了与农场的共同联系，并确定了可能的食物载体，即生饮牛奶（RDM）。微生物学调查，包括 PCR，在 RDM 样本中鉴定出 STEC O157:H7 的存在。对来自人类粪便标本、动物粪便样本和 RDM 的 STEC O157:H7 的核心基因组单核苷酸多态性（SNP）数据进行分析表明，分离株之间存在一个 SNP 差异，因此具有密切的遗传相关性。采取的控制措施包括暂停销售和召回 RDM，以及限制公众进入农场的部分区域。传统的流行病学监测与先进的实验室方法的成功结合，用于从人类、动物和环境样本中检测和表征 STEC O157:H7，能够及时确定疫情的源头，并为疫情控制团队的决策提供证据支持，从而及时采取有效的控制措施。
