Islam Md Asiful, Khandker Shahad Saif, Alam Fahmida, Khalil Md Ibrahim, Kamal Mohammad Amjad, Gan Siew Hua
Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan. Malaysia.
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342. Bangladesh.
Curr Top Med Chem. 2017;17(12):1408-1428. doi: 10.2174/1568026617666170103163054.
Alzheimer's disease (AD), which largely affects the elderly, has become a global burden. Patients with AD have both short- and long-term memory impairments. The neuronal loss in AD occurs due to abnormally folded amyloid beta proteins and aggregation of hyperphosphorylated tau proteins in the brain. Eventually, amyloid plaques and neurofibrillary tangles are formed, which subsequently disintegrate the neuronal transport system. There are several factors which are involved in AD pathogenesis, including oxidative stress, inflammation and the presence of metal ions. The modern therapies utilized for AD treatment have many adverse effects, driving the quest for more safe and effective medications. Many dietary components, including different types of fruits, vegetables, spices, and marine products as well as a Mediterranean diet, are a good source of antioxidants and have anti-inflammatory properties, with many showing substantial potential against AD pathogenesis. In this review, we discuss the potential of these foods for treating AD and opportunities for developing disease-targeted drugs from active compounds extracted from natural dietary products.
阿尔茨海默病（AD）主要影响老年人，已成为一项全球负担。AD患者存在短期和长期记忆障碍。AD中的神经元损失是由于大脑中异常折叠的β-淀粉样蛋白和过度磷酸化的tau蛋白聚集所致。最终，形成淀粉样斑块和神经原纤维缠结，随后破坏神经元转运系统。AD发病机制涉及多个因素，包括氧化应激、炎症和金属离子的存在。用于AD治疗的现代疗法有许多不良反应，这促使人们寻求更安全有效的药物。许多饮食成分，包括不同种类的水果、蔬菜、香料、海产品以及地中海饮食，都是抗氧化剂的良好来源，具有抗炎特性，其中许多对AD发病机制显示出巨大潜力。在本综述中，我们讨论了这些食物治疗AD的潜力以及从天然饮食产品中提取的活性化合物开发疾病靶向药物的机会。
