Taranov O S, Yakubitskiy S N, Nepomnyashchikh T S, Nesterov A E, Shchelkunov S N
State Research Center of Virology and Biotechnology VECTOR, Kol'tsovo, Novosibirsk region, 630559 Russia.
Acta Naturae. 2016 Oct-Dec;8(4):110-117.
We propose a model of rheumatoid arthritis (RA) induced in outbred guinea pigs using a single subcutaneous injection of complete Freund's adjuvant to the hind paw. Histological examination of this model shows fibrin deposition on the surface of the synovial membrane, leukocyte infiltration of the synovial membrane and adjacent tissues, proliferation of the granulation tissue, and emergence of angioid areas, characteristic of RA. The cell response appears as an increase in the plasma cell count and development of follicle-like lymphoid infiltrates; erosion of the articular surface of the cartilage, frequently with deep cartilage destruction over large areas; and epiphysiopathy. The high reproducibility of arthritis induction in this RA model has been demonstrated. The proposed model is promising for the assessment of anti-arthritis preparations and dosage regimens.
我们提出了一种在远交豚鼠中诱导类风湿性关节炎（RA）的模型，方法是在后爪单次皮下注射完全弗氏佐剂。对该模型的组织学检查显示，滑膜表面有纤维蛋白沉积、滑膜及相邻组织有白细胞浸润、肉芽组织增生以及出现类血管区域，这些都是RA的特征。细胞反应表现为浆细胞数量增加以及出现滤泡样淋巴浸润；软骨关节表面糜烂，常常伴有大面积深层软骨破坏；以及骺病。该RA模型诱导关节炎的高重现性已得到证实。所提出的模型在评估抗关节炎制剂和给药方案方面很有前景。
