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通用且可重复使用的呼吸道防护病毒灭活系统。

Universal and reusable virus deactivation system for respiratory protection.

机构信息

Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul, 130-701, Korea.

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 1H9, Canada.

出版信息

Sci Rep. 2017 Jan 4;7:39956. doi: 10.1038/srep39956.

DOI:10.1038/srep39956
PMID:28051158
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5209731/
Abstract

Aerosolized pathogens are a leading cause of respiratory infection and transmission. Currently used protective measures pose potential risk of primary/secondary infection and transmission. Here, we report the development of a universal, reusable virus deactivation system by functionalization of the main fibrous filtration unit of surgical mask with sodium chloride salt. The salt coating on the fiber surface dissolves upon exposure to virus aerosols and recrystallizes during drying, destroying the pathogens. When tested with tightly sealed sides, salt-coated filters showed remarkably higher filtration efficiency than conventional mask filtration layer, and 100% survival rate was observed in mice infected with virus penetrated through salt-coated filters. Viruses captured on salt-coated filters exhibited rapid infectivity loss compared to gradual decrease on bare filters. Salt-coated filters proved highly effective in deactivating influenza viruses regardless of subtypes and following storage in harsh environmental conditions. Our results can be applied in obtaining a broad-spectrum, airborne pathogen prevention device in preparation for epidemic and pandemic of respiratory diseases.

摘要

气溶胶传播的病原体是导致呼吸道感染和传播的主要原因。目前使用的防护措施存在原发/继发感染和传播的潜在风险。在这里，我们报告了一种通用的、可重复使用的病毒灭活系统的开发，该系统通过用氯化钠盐对手术口罩的主要纤维过滤单元进行功能化来实现。纤维表面的盐涂层在暴露于病毒气溶胶时溶解，并在干燥时重新结晶，从而破坏病原体。当用密封严密的侧面进行测试时，涂盐过滤器的过滤效率明显高于传统口罩过滤层，并且通过涂盐过滤器穿透的病毒感染的小鼠的存活率为 100%。与裸过滤器上逐渐减少相比，涂盐过滤器上捕获的病毒表现出快速的感染力丧失。盐涂层过滤器在灭活流感病毒方面非常有效，无论亚型如何，并且在恶劣的环境条件下储存后也是如此。我们的研究结果可应用于获得广谱的、空气传播病原体预防装置，以应对呼吸道疾病的流行和大流行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a47/5209731/6acbc0e37cde/srep39956-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a47/5209731/56ac68fe0aa3/srep39956-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a47/5209731/f70a6428120a/srep39956-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a47/5209731/95683fb1401f/srep39956-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a47/5209731/6acbc0e37cde/srep39956-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a47/5209731/56ac68fe0aa3/srep39956-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a47/5209731/f70a6428120a/srep39956-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a47/5209731/95683fb1401f/srep39956-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a47/5209731/6acbc0e37cde/srep39956-f4.jpg

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PLoS One. 2015 Jul 31;10(7):e0134431. doi: 10.1371/journal.pone.0134431. eCollection 2015.
3
Guidance on the use of respiratory and facial protection equipment.呼吸和面部防护设备使用指南。
Trans Indian Natl Acad Eng. 2020;5(2):333-336. doi: 10.1007/s41403-020-00110-0. Epub 2020 May 29.
4
Face masks to fight against COVID-19 pandemics: A comprehensive review of materials, design, technology and product development.用于抗击新冠疫情的口罩：材料、设计、技术及产品开发的全面综述
J Ind Text. 2022 Jun;51(3 Suppl):3613S-3647S. doi: 10.1177/15280837211069869.
5
Functionalization of Polymer-Wrapped Silver Nanoclusters and Potential Applications as Antimicrobial Mask Materials.聚合物包裹的银纳米团簇的功能化及其作为抗菌口罩材料的潜在应用
ACS Omega. 2023 Nov 3;8(45):42678-42688. doi: 10.1021/acsomega.3c05454. eCollection 2023 Nov 14.
6
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Front Public Health. 2023 Jun 16;11:1161881. doi: 10.3389/fpubh.2023.1161881. eCollection 2023.
7
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