Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, Gyeonggi-do, 16419, Republic of Korea.
Center for Biologics, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Sci Rep. 2021 Jan 13;11(1):979. doi: 10.1038/s41598-020-78929-4.
Influenza, one of the most contagious and infectious diseases, is predominantly transmitted through aerosols, leading to the development of filter-based protective equipment. Though the currently available filters are effective at removing submicron-sized particulates, filter materials with enhanced virus-capture efficiency are still in demand. Coating or chemically modifying filters with molecules capable of binding influenza viruses has received attention as a promising approach for the production of virus-capturing filters. For this purpose, tannic acid (TA), a plant-derived polyphenol, is a promising molecule for filter functionalization because of its antiviral activities and ability to serve as a cost-efficient adhesive for various materials. This study demonstrates the facile preparation of TA-functionalized high-efficiency particulate air (HEPA) filter materials and their efficiency in influenza virus capture. Polypropylene HEPA filter fabrics were coated with TA via a dipping/washing process. The TA-functionalized HEPA filter (TA-HF) exhibits a high in-solution virus capture efficiency of up to 2,723 pfu/mm within 10 min, which is almost two orders of magnitude higher than that of non-functionalized filters. This result suggests that the TA-HF is a potent anti-influenza filter that can be used in protective equipment to prevent the spread of pathogenic viruses.
流感是一种最具传染性和感染力的疾病之一，主要通过气溶胶传播，导致基于过滤的防护设备的发展。虽然目前可用的过滤器能够有效去除亚微米大小的颗粒物，但仍需要具有更高病毒捕获效率的过滤材料。用能够结合流感病毒的分子对过滤器进行涂层或化学修饰，已成为生产病毒捕获过滤器的一种很有前途的方法。为此，鞣酸（TA）作为一种植物来源的多酚，由于其抗病毒活性和作为各种材料的经济高效粘合剂的能力，是用于过滤器功能化的一种很有前途的分子。本研究展示了 TA 功能化高效空气过滤器（HEPA）材料的简便制备及其在流感病毒捕获中的效率。通过浸渍/洗涤工艺将 TA 涂覆到聚丙烯 HEPA 过滤织物上。TA 功能化的 HEPA 过滤器（TA-HF）在溶液中表现出高达 2723 pfu/mm 的高病毒捕获效率，在 10 分钟内几乎高出两个数量级，这表明 TA-HF 是一种有效的抗流感过滤器，可以用于防护设备中，以防止致病性病毒的传播。
