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具有可调组成和类酶活性的 AuPt 合金纳米结构用于检测硫代硫酸盐的比色法。

AuPt Alloy Nanostructures with Tunable Composition and Enzyme-like Activities for Colorimetric Detection of Bisulfide.

机构信息

Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, College of Advanced Materials and Energy, Institute of Surface Micro and Nano Materials, Xuchang University, Henan 461000, P.R. China.

Wenzhou Institute of biomaterials and engineering, CNITECH, CAS, Zhejiang 325001, P.R. China.

出版信息

Sci Rep. 2017 Jan 4;7:40103. doi: 10.1038/srep40103.

DOI:10.1038/srep40103
PMID:28051159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5209660/
Abstract

Tuning the enzyme-like activity and studying the interaction between biologically relevant species and nano-enzymes may facilitate the applications of nanostructures in mimicking natural enzymes. In this work, AuPt alloy nanoparticles (NPs) with varying compositions were prepared through a facile method by co-reduction of Au and Pt in aqueous solutions. The composition could be tuned easily by adjusting the molar ratios of added Pt to Au. It was found that both peroxidase-like and oxidase-like activity of AuPt alloy NPs were highly dependent on the alloy compositions, which thus suggesting an effective way to tailor their catalytic properties. By investigating the inhibitory effects of HS on the enzyme-like activity of AuPt alloy NPs and natural enzyme, we have developed a method for colorimetric detection of HS and evaluation of the inhibiting effects of inhibitors on natural and artificial enzymes. In addition, the responsive ability of this method was influenced largely by the composition: AuPt alloy NPs show much lower limit of detection for HS than Pt NPs while Pt NPs show wider linear range than AuPt alloy NPs. This study suggests the facile way not only for synthesis of alloy nanostructures, but also for tuning their catalytic activities and for use in bioanalysis.

摘要

调整酶样活性并研究生物相关物种与纳米酶之间的相互作用，可能有助于将纳米结构应用于模拟天然酶。在这项工作中，通过在水溶液中共同还原 Au 和 Pt，制备了具有不同组成的 AuPt 合金纳米颗粒（NPs）。通过调整添加的 Pt 与 Au 的摩尔比，可以轻松调整组成。结果发现，AuPt 合金 NPs 的过氧化物酶样和氧化酶样活性均高度依赖于合金组成，这表明可以有效地调整其催化性能。通过研究 HS 对 AuPt 合金 NPs 和天然酶的酶样活性的抑制作用，我们开发了一种用于 HS 的比色检测以及评估抑制剂对天然和人工酶的抑制作用的方法。此外，这种方法的响应能力在很大程度上受到组成的影响：与 Pt NPs 相比，AuPt 合金 NPs 对 HS 的检测限低得多，而 Pt NPs 的线性范围比 AuPt 合金 NPs 宽。这项研究不仅为合金纳米结构的合成提供了一种简便的方法，而且为调整其催化活性以及在生物分析中的应用提供了一种简便的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/5209660/97796b54f584/srep40103-f8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/5209660/b63c8371dff3/srep40103-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/5209660/394beee29838/srep40103-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/5209660/91f3bc2cf092/srep40103-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/5209660/97796b54f584/srep40103-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/5209660/5908c4520652/srep40103-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/5209660/8590f57b1265/srep40103-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/5209660/7c9e382ee63a/srep40103-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/5209660/b24a1daa675a/srep40103-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/5209660/b63c8371dff3/srep40103-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/5209660/394beee29838/srep40103-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/5209660/91f3bc2cf092/srep40103-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/5209660/97796b54f584/srep40103-f8.jpg

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