Lin Qian, Ma Leina, Liu Zhantao, Yang Zhihong, Wang Jin, Liu Jia, Jiang Guohui
College of Medicine, Qingdao University, Qingdao, China.
The Department of Oncology, The First Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Oncotarget. 2017 Feb 28;8(9):15961-15970. doi: 10.18632/oncotarget.14392.
Unlike genetics, epigenetics involves the modification of genome without changes in DNA sequences, including DNA methylation, histone modification, chromatin remodeling and noncoding RNA regulation. MicroRNA (miRNA), a member of noncoding RNAs superfamily, participates in RNA interference through a unique mechanism. Currently, microRNAs have been found to be regulated by some natural compounds. Through altering the expression of miRNAs and influencing the downstream signaling pathways or target genes, several natural compounds exhibit its bioactivity in the prevention, diagnosis, therapy, prognosis and drug resistance of human diseases, such as cancer. In this review, several natural compounds and their studies about miRNA-related action mechanism were summarized. These studies provide a new insight into action mechanism by which natural compound exerts its bioactivity and a novel treatment strategy, demonstrating natural compound a promising remedy for clinical treatments.
与遗传学不同，表观遗传学涉及基因组修饰但DNA序列不变，包括DNA甲基化、组蛋白修饰、染色质重塑和非编码RNA调控。微小RNA（miRNA）是非编码RNA超家族的成员，通过独特机制参与RNA干扰。目前，已发现微小RNA受一些天然化合物调控。通过改变miRNA的表达并影响下游信号通路或靶基因，几种天然化合物在人类疾病如癌症的预防、诊断、治疗、预后和耐药性方面展现出生物活性。在本综述中，总结了几种天然化合物及其与miRNA相关作用机制的研究。这些研究为天然化合物发挥生物活性的作用机制提供了新见解以及一种新的治疗策略，表明天然化合物是一种有前景的临床治疗药物。
