RNA结合蛋白在miRNA活性调控中的作用：聚焦神经元功能

Loffreda Alessia, Rigamonti Aurora, Barabino Silvia M L, Lenzken Silvia C

Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.

Biomolecules. 2015 Sep 30;5(4):2363-87. doi: 10.3390/biom5042363.

Posttranscriptional modifications of messenger RNAs (mRNAs) are key processes in the fine-tuning of cellular homeostasis. Two major actors in this scenario are RNA binding proteins (RBPs) and microRNAs (miRNAs) that together play important roles in the biogenesis, turnover, translation and localization of mRNAs. This review will highlight recent advances in the understanding of the role of RBPs in the regulation of the maturation and the function of miRNAs. The interplay between miRNAs and RBPs is discussed specifically in the context of neuronal development and function.

信使核糖核酸（mRNA）的转录后修饰是细胞稳态微调中的关键过程。在这种情况下，两个主要参与者是RNA结合蛋白（RBP）和微小核糖核酸（miRNA），它们在mRNA的生物合成、周转、翻译和定位中共同发挥重要作用。本综述将重点介绍在理解RBP在miRNA成熟和功能调节中的作用方面的最新进展。miRNA和RBP之间的相互作用将在神经元发育和功能的背景下进行具体讨论。