• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

塞内加尔达喀尔恶性疟原虫中Pf基因多态性与对奎宁敏感性之间的关联

Association between Polymorphisms in the Pf Gene and Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal.

作者信息

Gendrot Mathieu, Diawara Silman, Madamet Marylin, Kounta Mame Bou, Briolant Sébastien, Wade Khalifa Ababacar, Fall Mansour, Benoit Nicolas, Nakoulima Aminata, Amalvict Rémy, Diémé Yaya, Fall Bécaye, Wade Boubacar, Diatta Bakary, Pradines Bruno

机构信息

Unité de Parasitologie et d'Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France.

Aix Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France.

出版信息

Antimicrob Agents Chemother. 2017 Feb 23;61(3). doi: 10.1128/AAC.01183-16. Print 2017 Mar.

DOI:10.1128/AAC.01183-16
PMID:28052850
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5328570/
Abstract

Polymorphisms and the overexpression of transporter genes, especially of the ATP-binding cassette superfamily, have been involved in antimalarial drug resistance. The objective of this study was to use 77 Senegalese isolates to evaluate the association between the number of Asn residues in the polymorphic microsatellite region of the multidrug resistance 6 gene (Pf) and the susceptibility to antimalarials. A significant association was observed between the presence of 7 or 9 Asn repeats and reduced susceptibility to quinine.

摘要

多态性以及转运蛋白基因（尤其是ATP结合盒超家族基因）的过表达与抗疟药耐药性有关。本研究的目的是使用77株塞内加尔分离株，评估多药耐药6基因（Pf）多态性微卫星区域中天冬酰胺（Asn）残基数量与对抗疟药敏感性之间的关联。观察到存在7个或9个Asn重复序列与对奎宁的敏感性降低之间存在显著关联。

相似文献

1
Association between Polymorphisms in the Pf Gene and Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal.塞内加尔达喀尔恶性疟原虫中Pf基因多态性与对奎宁敏感性之间的关联
Antimicrob Agents Chemother. 2017 Feb 23;61(3). doi: 10.1128/AAC.01183-16. Print 2017 Mar.
2
Role of Pfmdr1 in in vitro Plasmodium falciparum susceptibility to chloroquine, quinine, monodesethylamodiaquine, mefloquine, lumefantrine, and dihydroartemisinin.Pfmdr1在恶性疟原虫对氯喹、奎宁、单去乙基氨喹啉、甲氟喹、本芴醇和双氢青蒿素的体外易感性中的作用。
Antimicrob Agents Chemother. 2014 Dec;58(12):7032-40. doi: 10.1128/AAC.03494-14. Epub 2014 Sep 8.
3
Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal.塞内加尔达喀尔恶性疟原虫分离株中，RING E3泛素蛋白连接酶基因多态性与对传统抗疟药物的体外敏感性之间不存在关联。
Antimicrob Agents Chemother. 2016 Jul 22;60(8):5010-3. doi: 10.1128/AAC.03105-15. Print 2016 Aug.
4
Repeat polymorphisms in the low-complexity regions of Plasmodium falciparum ABC transporters and associations with in vitro antimalarial responses.恶性疟原虫ABC转运蛋白低复杂性区域的重复多态性及其与体外抗疟反应的关联。
Antimicrob Agents Chemother. 2013 Dec;57(12):6196-204. doi: 10.1128/AAC.01465-13. Epub 2013 Sep 30.
5
Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin.恶性疟原虫疟疾中pfmdr1拷贝数的减少会增加对甲氟喹、卤泛群、奎宁和青蒿素的易感性。
J Infect Dis. 2006 Aug 15;194(4):528-35. doi: 10.1086/507115. Epub 2006 Jul 11.
6
Plasmodium falciparum Polymorphisms associated with ex vivo drug susceptibility and clinical effectiveness of artemisinin-based combination therapies in Benin.贝宁地区间日疟原虫多态性与基于青蒿素联合疗法的体外药物敏感性和临床疗效的关系。
Antimicrob Agents Chemother. 2014;58(1):1-10. doi: 10.1128/AAC.01790-12. Epub 2013 Oct 7.
7
Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance.恶性疟原虫 ABC 转运蛋白基因的新型多态性与主要 ACT 抗疟药物耐药性相关。
PLoS One. 2011;6(5):e20212. doi: 10.1371/journal.pone.0020212. Epub 2011 May 25.
8
In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos).老挝新发恶性疟原虫分离株的体外抗疟药物敏感性及pfcrt基因突变情况
Am J Trop Med Hyg. 2007 Feb;76(2):245-50.
9
In vitro activity of Proveblue (methylene blue) on Plasmodium falciparum strains resistant to standard antimalarial drugs.体外实验中 Proveblue（亚甲蓝）对耐标准抗疟药物的恶性疟原虫株的活性。
Antimicrob Agents Chemother. 2011 May;55(5):2472-4. doi: 10.1128/AAC.01466-10. Epub 2011 Feb 22.
10
Confirmation of Plasmodium falciparum in vitro resistance to monodesethylamodiaquine and chloroquine in Dakar, Senegal, in 2015.2015年在塞内加尔达喀尔对恶性疟原虫对单去乙基阿莫地喹和氯喹的体外耐药性的确认
Malar J. 2017 Mar 16;16(1):118. doi: 10.1186/s12936-017-1773-4.

引用本文的文献

1
ATM1, an essential conserved transporter in Apicomplexa, bridges mitochondrial and cytosolic [Fe-S] biogenesis.ATM1，一种在顶复门生物中必不可少的保守转运蛋白，连接线粒体和细胞质[Fe-S]生物发生。
PLoS Pathog. 2024 Sep 30;20(9):e1012593. doi: 10.1371/journal.ppat.1012593. eCollection 2024 Sep.
2
Prevalence of malaria resistance-associated mutations in circulating in 2017-2018, Bo, Sierra Leone.2017 - 2018年在塞拉利昂博城流行的疟疾抗性相关突变的流行情况。
Front Microbiol. 2022 Dec 2;13:1059695. doi: 10.3389/fmicb.2022.1059695. eCollection 2022.
3
Absence of Association between Methylene Blue Reduced Susceptibility and Polymorphisms in 12 Genes Involved in Antimalarial Drug Resistance in African .非洲地区亚甲蓝敏感性降低与12个抗疟药物耐药相关基因多态性之间不存在关联。
Pharmaceuticals (Basel). 2021 Apr 9;14(4):351. doi: 10.3390/ph14040351.
4
Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa?在东南亚，k13 和疟原虫裂殖子表面蛋白 2（plasmepsin II）基因与对青蒿素衍生物和哌喹的耐药性有关，那么这些基因是否可用于监测非洲的耐药性？
Malar J. 2019 Aug 23;18(1):285. doi: 10.1186/s12936-019-2916-6.
5
Contribution of the French army health service in support of expertise and research in infectiology in Africa.法国军队卫生服务在支持非洲传染病学专业知识与研究方面的贡献。
New Microbes New Infect. 2018 Jun 4;26:S78-S82. doi: 10.1016/j.nmni.2018.05.008. eCollection 2018 Nov.
6
Malaria, tuberculosis and HIV: what's new? Contribution of the Institut Hospitalo-Universitaire Méditerranée Infection in updated data.疟疾、结核病与艾滋病：有哪些新情况？地中海感染大学医院研究所对最新数据的贡献。
New Microbes New Infect. 2018 Jul 4;26:S23-S30. doi: 10.1016/j.nmni.2018.06.003. eCollection 2018 Nov.
7
Absence of a High Level of Duplication of the Plasmepsin II Gene in Africa.在非洲不存在高水平的疟原虫Ⅱ型裂殖子蛋白基因重复。
Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.00374-18. Print 2018 Nov.

本文引用的文献

1
PfMDR2 and PfMDR5 are dispensable for Plasmodium falciparum asexual parasite multiplication but change in vitro susceptibility to anti-malarial drugs.PfMDR2和PfMDR5对于恶性疟原虫无性寄生虫增殖并非必需，但会改变体外对抗疟药物的敏感性。
Malar J. 2015 Feb 14;14:76. doi: 10.1186/s12936-015-0581-y.
2
Multinormal in vitro distribution of Plasmodium falciparum susceptibility to piperaquine and pyronaridine.恶性疟原虫对哌喹和咯萘啶的体外敏感性呈多正态分布。
Malar J. 2015 Feb 5;14:49. doi: 10.1186/s12936-015-0586-6.
3
Role of Pfmdr1 in in vitro Plasmodium falciparum susceptibility to chloroquine, quinine, monodesethylamodiaquine, mefloquine, lumefantrine, and dihydroartemisinin.Pfmdr1在恶性疟原虫对氯喹、奎宁、单去乙基氨喹啉、甲氟喹、本芴醇和双氢青蒿素的体外易感性中的作用。
Antimicrob Agents Chemother. 2014 Dec;58(12):7032-40. doi: 10.1128/AAC.03494-14. Epub 2014 Sep 8.
4
Spread of artemisinin resistance in Plasmodium falciparum malaria.疟原虫青蒿素耐药性的传播。
N Engl J Med. 2014 Jul 31;371(5):411-23. doi: 10.1056/NEJMoa1314981.
5
Repeat polymorphisms in the low-complexity regions of Plasmodium falciparum ABC transporters and associations with in vitro antimalarial responses.恶性疟原虫ABC转运蛋白低复杂性区域的重复多态性及其与体外抗疟反应的关联。
Antimicrob Agents Chemother. 2013 Dec;57(12):6196-204. doi: 10.1128/AAC.01465-13. Epub 2013 Sep 30.
6
Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies.柬埔寨青蒿素耐药性恶性疟原虫的新型表型检测方法：体外和体内药物反应研究。
Lancet Infect Dis. 2013 Dec;13(12):1043-9. doi: 10.1016/S1473-3099(13)70252-4. Epub 2013 Sep 11.
7
In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger transporter (Pfnhe-1) gene in 393 isolates from Dakar, Senegal.来自塞内加尔达喀尔的 393 个分离株中，恶性疟原虫 Na+/H+ 交换转运蛋白（Pfnhe-1）基因的奎宁体外敏感性与微卫星变异。
Malar J. 2013 Jun 7;12:189. doi: 10.1186/1475-2875-12-189.
8
In vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to major ACT drugs and polymorphisms in potential target genes.中国-缅甸边境地区恶性疟原虫对主要复方青蒿素类抗疟药的体外敏感性及潜在靶标基因的多态性
PLoS One. 2012;7(5):e30927. doi: 10.1371/journal.pone.0030927. Epub 2012 May 31.
9
The F423Y mutation in the pfmdr2 gene and mutations N51I, C59R, and S108N in the pfdhfr gene are independently associated with pyrimethamine resistance in Plasmodium falciparum isolates.疟原虫 Pfmdr2 基因中的 F423Y 突变和 pfdhfr 基因中的 N51I、C59R 和 S108N 突变均与疟原虫分离株中的嘧啶耐药性独立相关。
Antimicrob Agents Chemother. 2012 May;56(5):2750-2. doi: 10.1128/AAC.05618-11. Epub 2012 Feb 6.
10
Ex vivo susceptibility of Plasmodium falciparum isolates from Dakar, Senegal, to seven standard anti-malarial drugs.塞内加尔达喀尔地区分离的恶性疟原虫对 7 种标准抗疟药物的体外敏感性。
Malar J. 2011 Oct 20;10:310. doi: 10.1186/1475-2875-10-310.