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疟疾、结核病与艾滋病:有哪些新情况?地中海感染大学医院研究所对最新数据的贡献。

Malaria, tuberculosis and HIV: what's new? Contribution of the Institut Hospitalo-Universitaire Méditerranée Infection in updated data.

作者信息

Almeras Lionel, Basco Leonardo K, Sokhna Cheikh, Ranque Stéphane, Parola Philippe, Devaux Christian, Brouqui Philippe, Drancourt Michel, Pradines Bruno

机构信息

Unité Parasitologie et entomologie, Département des maladies infectieuses, Institut de recherche biomédicale des armées, Institut Hospitalo-Universitaire (IHU)-Méditerranée Infection, Marseille, France.

Aix-Marseille Université, IRD, AP-HM, SSA, VITROME, Marseille, France.

出版信息

New Microbes New Infect. 2018 Jul 4;26:S23-S30. doi: 10.1016/j.nmni.2018.06.003. eCollection 2018 Nov.

DOI:10.1016/j.nmni.2018.06.003
PMID:30402240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6205578/
Abstract

The Institut Hospitalo-Universitaire Méditerranée Infection is positioned for the diagnosis, prevention and treatment of the 'big three' killer diseases: malaria, tuberculosis and HIV. We implemented the use of new diagnostic samples such as stools and new diagnostic tests such as mass spectrometry for the dual identification of vectors and pathogens. Furthermore, advances in the prevention and treatment of malaria and tuberculosis are reviewed, along with advances in the understanding of the role of microbiota in the resistance to HIV infection. These achievements represent a major step towards a better management of the 'big three' diseases worldwide.

摘要

地中海感染大学医院研究所致力于疟疾、结核病和艾滋病这三大致命疾病的诊断、预防和治疗。我们采用了新的诊断样本(如粪便)和新的诊断测试(如质谱分析法)来双重鉴定病媒和病原体。此外,还综述了疟疾和结核病预防与治疗方面的进展,以及对微生物群在抵抗艾滋病毒感染中所起作用的认识进展。这些成果是朝着在全球更好地管理这三大疾病迈出的重要一步。

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Plasmodium falciparum Recrudescence Two Years after Treatment of an Uncomplicated Infection without Return to an Area Where Malaria Is Endemic.恶性疟原虫复燃 2 年,在无返回疟疾流行地区治疗单纯感染后。
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The global burden of tuberculosis: results from the Global Burden of Disease Study 2015.全球结核病负担:来自 2015 年全球疾病负担研究的结果。
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Infect Genet Evol. 2018 Sep;63:410-419. doi: 10.1016/j.meegid.2017.09.009. Epub 2017 Sep 15.
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MALDI-TOF MS identification of Anopheles gambiae Giles blood meal crushed on Whatman filter papers.基质辅助激光解吸电离飞行时间质谱法鉴定在沃特曼滤纸上碾碎的冈比亚按蚊吉尔斯血餐。
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The implementation of long-lasting insecticidal bed nets has differential effects on the genetic structure of the African malaria vectors in the Anopheles gambiae complex in Dielmo, Senegal.长效杀虫蚊帐的实施对塞内加尔迪埃洛的冈比亚按蚊复合体中非洲疟疾传播媒介的遗传结构产生了不同的影响。
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Field application of MALDI-TOF MS on mosquito larvae identification.基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)在蚊虫幼虫鉴定中的现场应用。
Parasitology. 2018 Apr;145(5):677-687. doi: 10.1017/S0031182017001354. Epub 2017 Aug 3.
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Sci Rep. 2017 Jul 24;7(1):6269. doi: 10.1038/s41598-017-06675-1.
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Stephanine from Stephania venosa (Blume) Spreng Showed Effective Antiplasmodial and Anticancer Activities, the Latter by Inducing Apoptosis through the Reverse of Mitotic Exit.来自毛叶轮环藤(Stephania venosa (Blume) Spreng)的千金藤宁显示出有效的抗疟和抗癌活性,后者通过逆转有丝分裂退出诱导细胞凋亡。
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Ex vivo activity of Proveblue, a methylene blue, against field isolates of Plasmodium falciparum in Dakar, Senegal from 2013-2015.2013-2015 年塞内加尔达喀尔地区分离的疟原虫野外株对 Proveblue(亚甲蓝)的体外活性。
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Malaria in Dielmo, a Senegal village: Is its elimination possible after seven years of implementation of long-lasting insecticide-treated nets?在塞内加尔的迪耶尔莫村:在实施长效驱虫蚊帐七年之后,疟疾能够被消除吗?
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