体外实验中 Proveblue（亚甲蓝）对耐标准抗疟药物的恶性疟原虫株的活性。
In vitro activity of Proveblue (methylene blue) on Plasmodium falciparum strains resistant to standard antimalarial drugs.
机构信息
Unité de Parasitologie, Institut de Recherche Biomédicale des Armées-Antenne de Marseille, Allée du Médecin-Colonel Jamot, Parc le Pharo, BP 60109, 13262 Marseille Cedex 7, France.
出版信息
Antimicrob Agents Chemother. 2011 May;55(5):2472-4. doi: 10.1128/AAC.01466-10. Epub 2011 Feb 22.
Abstract
The geometric mean 50% inhibitory concentration (IC50) for Proveblue, a methylene blue complying with the European Pharmacopoeia, was more active on 23 P. falciparum strains than chloroquine, quinine, mefloquine, monodesethylamodiaquine, and lumefantrine. We did not find significant associations between the Proveblue IC50 and polymorphisms in the pfcrt, pfmdr1, pfmdr2, pfmrp, and pfnhe-1 genes or the copy numbers of the pfmdr1 and pfmdr2 genes, all of which are involved in antimalarial resistance.
摘要
Proveblue（一种符合欧洲药典的亚甲蓝）的 50%抑制浓度（IC50）几何平均值在 23 株疟原虫中比氯喹、奎宁、甲氟喹、单去乙基阿莫地喹和青蒿琥酯更有效。我们没有发现 Proveblue 的 IC50 与参与抗疟药物耐药性的 pfcrt、pfmdr1、pfmdr2、pfmrp 和 pfnhe-1 基因的多态性或 pfmdr1 和 pfmdr2 基因的拷贝数之间存在显著关联。
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