Fusar-Poli Paolo
Department of Psychosis Studies, Institute of Psychiatry , Psychology and Neuroscience, King's College London, London, UK;
OASIS Service, South London and the Maudsley NHS Foundation Trust, London, UK.
Schizophr Bull. 2017 Jan;43(1):44-47. doi: 10.1093/schbul/sbw158.
The Clinical High-Risk state for psychosis (CHR-P) paradigm was introduced about 2 decades ago. Over this period of time accumulating knowledge has been gained. Conceptual advancements involve new knowledge into risk enrichment and the impact of recruitment strategies, specificity for prediction of psychotic and nonpsychotic mental disorders and heterogeneity of psychosis risk among the different CHR-P subgroups. The current special issue advances current knowledge on deconstructing the CHR-P paradigm across its 3 subgroups: genetic risk, attenuated psychotic symptoms, and short-lived and remitting psychotic episodes. A conceptual revision of the paradigm (Version II) is suggested and supported by 3 original studies published in this special issue.
精神病临床高危状态（CHR-P）范式大约在20年前被引入。在这段时间里，积累了越来越多的知识。概念上的进展包括关于风险富集的新知识、招募策略的影响、对精神病性和非精神病性精神障碍预测的特异性以及不同CHR-P亚组之间精神病风险的异质性。本期特刊推进了关于在CHR-P范式的三个亚组中进行解构的现有知识：遗传风险、精神病性症状减弱以及短暂性和缓解性精神病发作。本特刊发表的三项原创研究提出并支持了该范式的概念修订版（第二版）。
