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CSF-IgM measurement in neurovenereological disease.

作者信息

van Kamp G J, Wolters E C

机构信息

Department of Clinical Chemistry, Free University Hospital, Amsterdam, The Netherlands.

出版信息

Clin Chim Acta. 1989 Aug 31;183(3):295-300. doi: 10.1016/0009-8981(89)90363-x.

DOI:10.1016/0009-8981(89)90363-x
PMID:2805355
Abstract

An immune response within the central nervous system (CNS) is reflected by an increase of immunoglobulin concentrations in the cerebrospinal fluid. IgM is considered the first class of immunoglobulins to be increased after infection. Calculation of the IgM and IgG-index reflects immunological activity within the CNS. Insight in this activity is essential in the diagnosis of several neurological diseases, especially neurosyphilis. A new fast solid phase, double sandwich enzyme-immuno assay for the measurement of IgM in the CSF is described and applied in 71 neurovenereological patients.

摘要

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