Hische E A, Tutuarima J A, Wolters E C, van Trotsenburg L, van Eyk R V, Bos J D, Albert A, van der Helm H J
Department of Clinical Chemistry, Academic Hospital, University of Amsterdam, The Netherlands.
Clin Chem. 1988 Apr;34(4):665-7.
Serological and non-serological tests were performed in matched samples of cerebrospinal fluid and serum from 236 syphilitic patients. An increased IgG or IgM index, or both, was found about 70 times more often in symptomatic neurosyphilis than in latent syphilis without involvement of the central nervous system. An increased Ig index, together with a cell count greater than 5/microL, was only found in symptomatic neurosyphilis. Although the numbers of data are small, we conclude that the IgG and IgM indexes are valuable tests in the diagnosis of syphilitic involvement of the central nervous system.
对236例梅毒患者的脑脊液和血清配对样本进行了血清学和非血清学检测。有症状的神经梅毒患者中，IgG或IgM指数升高，或两者均升高的情况，比未累及中枢神经系统的潜伏梅毒患者中出现的频率高约70倍。仅在有症状的神经梅毒患者中发现Ig指数升高，同时细胞计数大于5/微升。尽管数据量较小，但我们得出结论，IgG和IgM指数在诊断中枢神经系统梅毒感染方面是有价值的检测方法。
