Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor, 43400 Serdang, Malaysia.
Evid Based Complement Alternat Med. 2012;2012:417953. doi: 10.1155/2012/417953. Epub 2012 Aug 29.
Elephantopus scaber has been traditionally used as liver tonic. However, the protective effect of E. scaber on ethanol-induced liver damage is still unclear. In this study, we have compared the in vivo hepatoprotective effect of E. scaber with Phyllanthus niruri on the ethanol-induced liver damage in mice. The total phenolic and total flavanoid content of E. scaber ethanol extract were determined in this study. Accelerating serum biochemical profiles (including AST, ALT, ALP, triglyceride, and total bilirubin) associated with fat drop and necrotic body in the liver section were observed in the mice treated with ethanol. Low concentration of E. scaber was able to reduce serum biochemical profiles and the fat accumulation in the liver. Furthermore, high concentration of E. scaber and positive control P. niruri were able to revert the liver damage, which is comparable to the normal control. Added to this, E. scaber did not possess any oral acute toxicity on mice. These results suggest the potential effect of this extract as a hepatoprotective agent towards-ethanol induced liver damage without any oral acute toxicity effect. These activities might be contributed, or at least in part, by its high total phenolic and flavonoid contents.
走马芹已被传统用于作为肝脏滋补品。然而，走马芹对乙醇诱导的肝损伤的保护作用尚不清楚。在本研究中，我们比较了走马芹与叶下珠对乙醇诱导的小鼠肝损伤的体内肝保护作用。本研究测定了走马芹乙醇提取物的总酚和总类黄酮含量。用乙醇处理的小鼠观察到与脂肪滴和肝坏死体相关的加速血清生化特征（包括 AST、ALT、ALP、甘油三酯和总胆红素）。低浓度的走马芹能够降低血清生化特征和肝脏中的脂肪堆积。此外，高浓度的走马芹和阳性对照叶下珠能够逆转肝损伤，与正常对照相当。此外，走马芹对小鼠没有任何口服急性毒性。这些结果表明，该提取物具有作为一种对乙醇诱导的肝损伤的肝保护剂的潜力，而没有任何口服急性毒性作用。这些活性可能是由其高总酚和类黄酮含量促成的，或者至少部分是由其促成的。
