Rodrigues Aquila, Gomes André, Marçal Pedro Henrique Ferreira, Dias-Souza Marcus Vinícius
Health Sciences Faculty, University Vale do Rio Doce, Governador Valadares, 35020 220 MG, Brazil; Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 35036 330, MG, Brazil.
Health Sciences Faculty, University Vale do Rio Doce, Governador Valadares, 35020 220 MG, Brazil; Oncology Specialized Nucleus, Governador Valadares, 35044 418 MG, Brazil; Integrated Pharmacology and Drug Interactions Research Group (GPqFAR), Brazil.
J Adv Res. 2017 Jan;8(1):55-61. doi: 10.1016/j.jare.2016.12.001. Epub 2016 Dec 16.
and are part of the human microbiota and are also important bacterial pathogens, for which therapeutic options are lacking nowadays. The combined administration of corticosteroids and antimicrobials is commonly used in the treatment of infectious diseases to control inflammatory processes and to minimize potential toxicity of antimicrobials, avoiding sequelae. Although different pharmaceutical dosage forms of antimicrobials combined to corticosteroids are available, studies on the interference of corticosteroids on the pharmacological activity of antimicrobials are scarce and controversial. Here, we provide evidence of the interference of dexamethasone on the pharmacological activity of clinically important antimicrobial drugs against biofilms and planktonic cells of and . Broth microdilution assays of minimal inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum biofilm eradication concentration (MBEC) of gentamicin, chloramphenicol, oxacillin, ceftriaxone and meropenem were conducted with and without the addition of dexamethasone. The effect of all drugs was abrogated by dexamethasone in their MIC, MBC, and MBEC, except gentamicin and meropenem, for which the MBC was not affected in some strains. The present study opens doors for more investigations on and effects and safety of the combination of antimicrobials and glucocorticoids.
[具体细菌名称1]和[具体细菌名称2]是人类微生物群的一部分，也是重要的细菌病原体，目前缺乏针对它们的治疗选择。皮质类固醇和抗菌药物联合给药常用于治疗传染病，以控制炎症过程并尽量减少抗菌药物的潜在毒性，避免后遗症。尽管有不同剂型的抗菌药物与皮质类固醇联合使用，但关于皮质类固醇对抗菌药物药理活性干扰的研究却很少且存在争议。在此，我们提供了地塞米松对临床上重要的抗菌药物针对[具体细菌名称1]和[具体细菌名称2]生物膜及浮游细胞药理活性干扰的证据。进行了庆大霉素、氯霉素、苯唑西林、头孢曲松和美罗培南在添加和不添加地塞米松情况下的最低抑菌浓度（MIC）、最低杀菌浓度（MBC）和最低生物膜清除浓度（MBEC）的肉汤微量稀释试验。除庆大霉素和美罗培南外，地塞米松使所有药物的MIC、MBC和MBEC效果均减弱，对于某些菌株，庆大霉素和美罗培南的MBC未受影响。本研究为更多关于[具体细菌名称1]和[具体细菌名称2]、抗菌药物与糖皮质激素联合使用的效果及安全性的研究打开了大门。
