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在韩国人群的非小细胞肺癌中未检测到游离或整合的高危型人乳头瘤病毒

No Detection of Episomal or Integrated High-Risk Human Papillomavirus in Nonsmall Cell Lung Carcinomas among Korean Population.

作者信息

Lee Jeong Eun, Lee Yong-Moon, Seong In-Ock, Kang Min-Woong, Lee Choong Sik, Kim Kyung-Hee

机构信息

Division of Pulmonology, Department of Internal Medicine, Chungnam National University, Daejeon, Korea.

Department of Pathology, Chungnam National University School of Medicine, Daejeon, Korea.

出版信息

Osong Public Health Res Perspect. 2016 Dec;7(6):356-359. doi: 10.1016/j.phrp.2016.10.004. Epub 2016 Oct 21.

DOI:10.1016/j.phrp.2016.10.004
PMID:28053840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5194223/
Abstract

OBJECTIVES

High-risk human papillomavirus (hrHPV) is known to be a representative cancer-causing agent in the genital and head and neck regions. Many studies have detected hrHPV DNA in nonsmall cell lung carcinoma. However, hrHPV-etiologic correlation in nonsmall cell lung carcinoma remains unclear. This study is designed to determine the prevalence of episomal or integrated hrHPV DNA in nonsmall cell lung carcinoma among the Korean population.

METHODS

Surgically resected nonsmall cell lung carcinoma tissues, including 134 cases of squamous cell carcinoma (SqCC) and 99 cases of adenocarcinoma (ADC), were examined. hybridization (ISH) for detecting episomal or integrated hrHPV DNA was performed using the INFORM HPV III Family 16 Probe (B) in the Ventana-validated assay. Anyplex II HPV28 detection kit based on real-time polymerase chain reaction was used for HPV DNA detection and genotyping.

RESULTS

All members of the study population were of Korean ethnicity. Episomal or integrated hrHPV DNA ISH analysis result was negative in all 233 cases. One SqCC of 89 samples (42 SqCCs and 47 ADCs) was positive for an hrHPV genotype by Anyplex II HPV28 detection kit.

CONCLUSION

Our finding did not demonstrate hrHPV-etiologic correlation in primary lung SqCC and ADC in the Korean population.

摘要

目的

高危型人乳头瘤病毒（hrHPV）是已知的生殖器及头颈部区域典型致癌因子。许多研究在非小细胞肺癌中检测到hrHPV DNA。然而，非小细胞肺癌中hrHPV与病因的相关性仍不明确。本研究旨在确定韩国人群非小细胞肺癌中游离型或整合型hrHPV DNA的流行情况。

方法

对手术切除的非小细胞肺癌组织进行检测，其中包括134例鳞状细胞癌（SqCC）和99例腺癌（ADC）。在经过Ventana验证的检测中，使用INFORM HPV III家族16型探针（B）进行杂交（ISH）以检测游离型或整合型hrHPV DNA。基于实时聚合酶链反应的Anyplex II HPV28检测试剂盒用于HPV DNA检测和基因分型。

结果

研究人群的所有成员均为韩国人。在所有233例病例中，游离型或整合型hrHPV DNA ISH分析结果均为阴性。在89份样本（42例SqCC和47例ADC）中，有1例SqCC通过Anyplex II HPV28检测试剂盒检测出hrHPV基因型呈阳性。

结论

我们的研究结果未显示韩国人群原发性肺SqCC和ADC中hrHPV与病因的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b6/5194223/9056edd1d9b1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b6/5194223/9056edd1d9b1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31b6/5194223/9056edd1d9b1/gr1.jpg

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2
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3
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J Cancer Res Clin Oncol. 2018 Dec;144(12):2367-2376. doi: 10.1007/s00432-018-2748-8. Epub 2018 Sep 17.
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4
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5
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