Dwivedi Deepak, Dwivedi Mona, Malviya Sourabh, Singh Vinod
Minor Forest Produce Processing and Research Center, Bhopal 462021, Madhya Pradesh, India.
Department of Mathematics and Bioinformatics, Maulana Aazad National Institute of Technology, Bhopal 462003, Madhya Pradesh, India.
J Tradit Complement Med. 2016 Apr 4;7(1):79-85. doi: 10.1016/j.jtcme.2015.12.002. eCollection 2017 Jan.
To investigate wound healing, antimicrobial and antioxidant activity of leaf extract of .
Methanolic extracts of leaf were studied for wound healing efficiency, and was assessed by the rate of wound contraction, tensile strength, breaking strength, hydroxyproline and hexosamine content, along with its effect on pro-inflammatory and anti-inflammatory cytokines was assessed using excision and incision model of wound repair in Wistar rats. Antimicrobial activity against ten microorganisms was also assessed. In vivo antioxidant activity was performed to understand the mechanism of wound healing potency.
The results indicated that extract has potent wound healing capacity as evident from the wound contraction and increased tensile strength. Hydroxyproline and hexosamine expression were also well correlated with the healing pattern observed. extract exhibited significant antimicrobial activity, also indicate that posses potent antioxidant activity by inhibition lipid peroxidation, reduce glutathione, superoxide dismutase level and increases catalase activity. During early wound healing phase TNF-α and IL-6 level were found to be up-regulated by treatment.
Increased wound contraction and tensile strength, augmented hydroxyproline and hexosamine content, antioxidative activity and moderate antimicrobial activity support the early wound healing exhibited by . Induction in cytokine production may be one of the mechanisms in accelerating the wound healing. Results suggest that may be useful in tropical management of wound healing.
研究[植物名称]叶提取物的伤口愈合、抗菌和抗氧化活性。
研究[植物名称]叶的甲醇提取物的伤口愈合效率，通过伤口收缩率、抗张强度、断裂强度、羟脯氨酸和己糖胺含量进行评估，同时使用Wistar大鼠的伤口修复切除和切口模型评估其对促炎和抗炎细胞因子的影响。还评估了对十种微生物的抗菌活性。进行体内抗氧化活性研究以了解伤口愈合效力的机制。
结果表明，[植物名称]提取物具有强大的伤口愈合能力，从伤口收缩和抗张强度增加可以明显看出。羟脯氨酸和己糖胺的表达也与观察到的愈合模式密切相关。[植物名称]提取物表现出显著的抗菌活性，[植物名称]提取物还通过抑制脂质过氧化、降低谷胱甘肽、超氧化物歧化酶水平和增加过氧化氢酶活性表明具有强大的抗氧化活性。在伤口愈合早期阶段，发现[植物名称]提取物处理可上调肿瘤坏死因子-α和白细胞介素-6水平。
伤口收缩和抗张强度增加、羟脯氨酸和己糖胺含量增加、抗氧化活性和适度的抗菌活性支持[植物名称]提取物表现出的早期伤口愈合。细胞因子产生的诱导可能是加速伤口愈合的机制之一。结果表明，[植物名称]提取物可能对热带地区伤口愈合的管理有用。
