Yagi Hiroshi, Sato Ryo, Nishio Kojiro, Arai Gaku, Soh Shigehiro, Okada Hiroshi
Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
J Tradit Complement Med. 2016 Jun 11;7(1):117-120. doi: 10.1016/j.jtcme.2016.05.008. eCollection 2017 Jan.
Lower urinary tract symptoms (LUTS) and sexual dysfunction (SDys) are common problems that affect quality of life (QOL) in elderly men. In addition to prescribed drugs, many over-the-counter medications including supplements are used to treat QOL diseases. Phosphodiesterase inhibitors are reported to be effective for both LUTS and SDys by increasing nitric oxide levels. French maritime pine bark extract Pycnogenol, which is a potent nitric oxide donor, is reported to be effective for SDys. However, no reports have been published on whether it ameliorates LUTS.
Open-labeled, randomized study. The effects of two supplements, Nokogiriyashi EX containing 160 mg saw palmetto (SP) extract per tablet and Edicare containing 10 mg of Pycnogenol, 115 mg of l-arginine and 92 mg of aspartate (PAA) per tablet on International Prostate Symptom Score (IPSS), IPSS-QOL, Overactive Bladder Symptom Score (OABSS), International Index of Erectile Function 5 (IIEF5), Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), urinary 8-OHdG and uroflowmetry (UFM) of total 40 men with LUTS and SDys were examined.
19 subjects were instructed to take two tablets of SP, on the other 20 were on four tablets of PAA for 16 weeks. IPSS and IPSS-QOL showed statistically significant improvements in both groups. OABSS and IIEF5 were significantly improved in the PAA group. Conversely, ICIQ-SF, 8-OHdG and UFM did not change in either group.
PAA might be an effective therapeutic alternative for elderly patients with LUTS and SDys.
下尿路症状（LUTS）和性功能障碍（SDys）是影响老年男性生活质量（QOL）的常见问题。除了处方药外，许多非处方药（包括补充剂）也被用于治疗生活质量相关疾病。据报道，磷酸二酯酶抑制剂可通过提高一氧化氮水平对LUTS和SDys均有效。法国滨海松树皮提取物碧萝芷是一种有效的一氧化氮供体，据报道对性功能障碍有效。然而，尚无关于其是否能改善LUTS的报道。
开放标签、随机研究。研究了两种补充剂对40例患有LUTS和SDys男性的国际前列腺症状评分（IPSS）、IPSS生活质量评分（IPSS-QOL）、膀胱过度活动症症状评分（OABSS）、国际勃起功能指数5（IIEF5）、尿失禁咨询问卷简表（ICIQ-SF）、尿8-羟基脱氧鸟苷（8-OHdG）和尿流率（UFM）的影响。这两种补充剂分别为每片含160毫克锯棕榈（SP）提取物的诺考吉里矢EX和每片含10毫克碧萝芷、115毫克L-精氨酸和92毫克天冬氨酸（PAA）的益得康。
19名受试者被指示服用两片SP，另外20名服用四片PAA，持续16周。两组的IPSS和IPSS-QOL均有统计学显著改善。PAA组的OABSS和IIEF5有显著改善。相反，两组的ICIQ-SF、8-OHdG和UFM均未改变。
PAA可能是老年LUTS和SDys患者的一种有效治疗选择。
