Bani Hani Amjad, Abu-Abeeleh Mahmoud, Al Kharabsheh Murad M, Qabba'ah Lubaba
The University of Jordan, Jordon University Hospital, Amman, Jordan.
The Islamic Hospital, Amman, Jordan.
Heart Surg Forum. 2016 Dec 21;19(6):E294-E296. doi: 10.1532/hsf.1612.
Antiphospholipid syndrome (APS) is an autoimmune hypercoagulable disorder characterized by thrombophilia, vascular thrombosis, and recurrent abortions associated with persistent antiphospholipid antibodies. APS may exist in its primary form, or more commonly is found to be associated with variety of rheumatic disorders, such as systemic lupus erythematosus. Cardiac involvement is not an uncommon complication in primary antiphospholipid patients. Libman-Sacks lesions are typically small, sessile, and wart-like, varying in size from 1-4 mm. Here we present an unusual case of a 37 year-old pregnant woman who suffered from heart failure associated with primary antiphospholipid syndrome and Libman-Sacks endocarditis, with large vegetations involving the mitral valve. The patient underwent mitral valve replacement with a mechanical prosthesis.
抗磷脂综合征（APS）是一种自身免疫性高凝疾病，其特征为易栓症、血管血栓形成以及与持续性抗磷脂抗体相关的反复流产。APS 可以以原发性形式存在，或者更常见的是与多种风湿性疾病相关，如系统性红斑狼疮。心脏受累在原发性抗磷脂综合征患者中是一种常见并发症。Libman-Sacks 病变通常较小、无蒂且呈疣状，大小从 1 - 4 毫米不等。在此，我们报告一例不寻常的病例，一名 37 岁孕妇患有与原发性抗磷脂综合征和 Libman-Sacks 心内膜炎相关的心力衰竭，二尖瓣有大的赘生物。该患者接受了机械瓣膜二尖瓣置换术。
