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Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism.针对线粒体和癌细胞代谢的抗癌药物的发现和递送中的机遇。
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Canonical and new generation anticancer drugs also target energy metabolism.经典和新一代抗癌药物也针对能量代谢。
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Targeting glucose metabolism: an emerging concept for anticancer therapy.靶向葡萄糖代谢:癌症治疗的新兴概念。
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Immune-mediated anti-tumor effects of metformin; targeting metabolic reprogramming of T cells as a new possible mechanism for anti-cancer effects of metformin.二甲双胍的免疫介导抗肿瘤作用;靶向 T 细胞的代谢重编程作为二甲双胍抗肿瘤作用的新可能机制。
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The Role of Aberrant Metabolism in Cancer: Insights Into the Interplay Between Cell Metabolic Reprogramming, Metabolic Syndrome, and Cancer.异常代谢在癌症中的作用:对细胞代谢重编程、代谢综合征和癌症之间相互作用的见解。
Front Oncol. 2020 Jun 11;10:942. doi: 10.3389/fonc.2020.00942. eCollection 2020.
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Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition.姜黄素通过抑制 mTOR-HIF1α 抑制丙酮酸激酶 M2,降低癌细胞的瓦博格效应。
Sci Rep. 2018 May 29;8(1):8323. doi: 10.1038/s41598-018-25524-3.
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Oxaloacetate induces apoptosis in HepG2 cells via inhibition of glycolysis.草酰乙酸通过抑制糖酵解诱导 HepG2 细胞凋亡。
Cancer Med. 2018 Apr;7(4):1416-1429. doi: 10.1002/cam4.1410. Epub 2018 Mar 13.
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Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model.在患者来源的原位异种移植(PDOX)小鼠模型中,重组蛋氨酸酶联合治疗可使替莫唑胺抑制BRAF V600E黑色素瘤。
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The wayward methyl group and the cascade to cancer.任性的甲基基团与癌症的连锁反应
Cell Cycle. 2017 May 3;16(9):825-829. doi: 10.1080/15384101.2017.1304330. Epub 2017 Mar 20.

本文引用的文献

1
Low-dose methotrexate enhances cycling of highly anaplastic cancer cells.低剂量甲氨蝶呤可增强高度间变癌细胞的循环。
Cell Cycle. 2017 Feb;16(3):280-285. doi: 10.1080/15384101.2016.1252883. Epub 2016 Nov 14.
2
Serine and one-carbon metabolism in cancer.癌症中的丝氨酸和一碳代谢。
Nat Rev Cancer. 2016 Oct;16(10):650-62. doi: 10.1038/nrc.2016.81. Epub 2016 Sep 16.
3
From Krebs to clinic: glutamine metabolism to cancer therapy.从克雷布斯循环到临床应用:谷氨酰胺代谢与癌症治疗
Nat Rev Cancer. 2016 Oct;16(10):619-34. doi: 10.1038/nrc.2016.71. Epub 2016 Jul 29.
4
High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant.高线粒体质量可识别出一群对化疗耐药的干细胞样癌细胞。
Oncotarget. 2015 Oct 13;6(31):30472-86. doi: 10.18632/oncotarget.5401.
5
Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets.抗缺氧特性意味着癌症干细胞对生理因子敏感,这提示了新的治疗靶点。
Cell Cycle. 2014;13(2):268-78. doi: 10.4161/cc.27031. Epub 2013 Nov 5.
6
Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle.烟酰胺核苷酸转氢酶(NNT)通过辅助因子平衡协调三羧酸(TCA)循环中的还原性羧化作用和葡萄糖分解代谢。
J Biol Chem. 2013 May 3;288(18):12967-77. doi: 10.1074/jbc.M112.396796. Epub 2013 Mar 15.
7
THE METABOLISM OF TUMORS IN THE BODY.体内肿瘤的新陈代谢
J Gen Physiol. 1927 Mar 7;8(6):519-30. doi: 10.1085/jgp.8.6.519.

The new anticancer era: Tumor metabolism targeting.

作者信息

Borriello Adriana, Della Ragione Fulvio

机构信息

a Department of Biochemistry, Biophysics and General Pathology , Second University of Naples , 80138 Naples , Italy.

出版信息

Cell Cycle. 2017 Feb 16;16(4):310-311. doi: 10.1080/15384101.2016.1271635. Epub 2017 Jan 5.

DOI:10.1080/15384101.2016.1271635
PMID:28055312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5324752/
Abstract
摘要