Boehringer Ingelheim Vetmedica GmbH, Binger Straße 173, 55216, Ingelheim, Germany.
PORCUS svinefagdyrlaeger og agronomer, Oerbaekvej 276, 5220, Odense, Denmark.
Acta Vet Scand. 2017 Jan 5;59(1):4. doi: 10.1186/s13028-016-0270-z.
Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant animal and economic losses worldwide. The infection is difficult to control and PRRSV elimination at local level requires coordinated intervention among multiple farms. This case study describes a successful elimination of PRRSV from all 12 herds on the Horne Peninsula, Denmark, using a combination of load, close, homogenise (LCH) using PRRSV type 2 modified-live vaccine, optimised pig flow, and'10 Golden Rules' (10GR) for biosecurity management. To the authors' knowledge, this is the first successful European PRRSV area elimination project documented in detail. The PRRSV type 2 modified-live vaccine was used as part of the LCH method in breeding herds. Complete or partial depopulation was performed in some infected herds. A simplified biosecurity protocol (10GR) based on the McREBEL™ system of pig flow management, was employed in all herds and at all times throughout the study.
At study commencement, all herds were infected with PRRSV, and most were actively shedding virus. In just over 18 months, all 12 herds on the Horne Peninsula were confirmed to be PRRSV negative by polymerase chain reaction testing and negative for antibodies against PRRSV by enzyme-linked immunosorbent assay testing. All herds were subsequently obtained 'Specific Pathogen Free' status for PRRSV.
This study provides compelling evidence suggesting that an area elimination plan combining LCH with PRRSV type 2 vaccination, optimised pig flow, and 10GR for biosecurity management can effectively eliminate PRRSV from a geographic area. Additionally this study confirms the value of a previously unpublished, simplified alternative to the McREBEL system for controlling PRRSV.
猪繁殖与呼吸综合征病毒（PRRSV）在全球范围内造成了重大的动物和经济损失。该感染难以控制，要在局部地区消除 PRRSV，需要多个农场之间的协调干预。本病例研究描述了丹麦霍恩半岛上的 12 个猪场如何通过使用 PRRSV 2 型活疫苗的负荷、封闭、均匀化（LCH）、优化猪群流动以及“10 大黄金法则”（10GR）的生物安全管理措施，成功地从所有 12 个猪场消除了 PRRSV。据作者所知，这是首次详细记录的欧洲 PRRSV 区域消除项目。PRRSV 2 型活疫苗被用作繁殖场 LCH 方法的一部分。一些感染的猪场进行了全部或部分清群。在所有猪场中，始终采用基于 McREBEL™猪群流动管理系统的简化生物安全方案（10GR）。
在研究开始时，所有猪场都感染了 PRRSV，并且大多数猪场都在持续排毒。在 18 个多月的时间里，霍恩半岛的所有 12 个猪场通过聚合酶链反应检测均被证实为 PRRSV 阴性，通过酶联免疫吸附试验检测均为 PRRSV 抗体阴性。所有猪场随后获得了 PRRSV 的“特定病原体阴性”状态。
本研究提供了令人信服的证据，表明将 LCH 与 PRRSV 2 型疫苗接种、优化猪群流动以及 10GR 用于生物安全管理相结合的区域消除计划，可以有效地从地理区域中消除 PRRSV。此外，本研究证实了之前未发表的、简化的 McREBEL 系统替代品在控制 PRRSV 方面的价值。
