Castaño-Castaño S, Garcia-Moll A, Morales-Navas M, Fernandez E, Sanchez-Santed F, Nieto-Escamez F
Universidad de Almeria, Departamento de Psicología, Ctra. Sacramento, 04120, La Cañada de San Urbano, Almería, Spain.
Universidad Miguel Hernández de Elche, Grupo de investigación en Neuroingeniería Biomédica, Av. de la Universidad S/N, Elche, Alicante, Spain.
Brain Res. 2017 Feb 15;1657:340-346. doi: 10.1016/j.brainres.2017.01.003. Epub 2017 Jan 3.
Transcranial direct current stimulation (tDCS) has proved to increase brain cortex plasticity and different models of brain damage. In this work, we have analyzed the effects of tDCS in an experimental model of amblyopia using Long-Evans rats. Animals were monocularly deprived between 12 and 75 postnatal days and visual cortex contralateral to the deprived eye was stimulated using anodal tDCS during 8days (20min/day). The effects of tDCS treatment on the visual function were evaluated by using the optomotor reflex of the animals as a measure of visual acuity. Results obtained indicate that monocular occlusion during the critical period lead to a reduction of visual acuity in monocular and binocular conditions. Stimulation with anodal tDCS produced a nearly full recovery in visual acuity of amblyopic animals. However, same stimulation protocol in healthy control animals produced a decrease of binocular visual acuity. These data indicate that tDCS can reverse the effects of monocular deprivation on visual acuity, although it is essential to use this technique in a controlled way due to the possible adverse effects on healthy individuals.
经颅直流电刺激（tDCS）已被证明可增强大脑皮层可塑性并改善不同类型的脑损伤。在本研究中，我们使用Long-Evans大鼠分析了tDCS在弱视实验模型中的作用。在出生后12至75天对动物进行单眼剥夺，并在8天内（每天20分钟）使用阳极tDCS刺激被剥夺眼对侧的视觉皮层。通过将动物的视动反射作为视力的指标来评估tDCS治疗对视觉功能的影响。所得结果表明，关键期的单眼遮挡会导致单眼和双眼条件下视力下降。阳极tDCS刺激使弱视动物的视力几乎完全恢复。然而，相同的刺激方案在健康对照动物中导致双眼视力下降。这些数据表明，tDCS可以逆转单眼剥夺对视力的影响，尽管由于可能对健康个体产生不良影响，必须以可控方式使用该技术。
