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Healthy ageing in 2016: Obesity in geroscience - is cellular senescence the culprit?

作者信息

Franceschi Claudio

机构信息

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Institute of Neurological Sciences of Bologna, Bellaria Hospital, Via Altura 3, 40139 Bologna, Italy.

出版信息

Nat Rev Endocrinol. 2017 Feb;13(2):76-78. doi: 10.1038/nrendo.2016.213. Epub 2017 Jan 6.

DOI:10.1038/nrendo.2016.213
PMID:28059157
Abstract
摘要

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A High-Fat High-Sucrose Diet Rapidly Alters Muscle Integrity, Inflammation and Gut Microbiota in Male Rats.高脂肪高糖饮食可迅速改变雄性大鼠的肌肉完整性、炎症和肠道微生物群。
Sci Rep. 2016 Nov 17;6:37278. doi: 10.1038/srep37278.
2
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J Clin Invest. 2016 Dec 1;126(12):4626-4639. doi: 10.1172/JCI88606. Epub 2016 Nov 7.
3
Inflammaging and 'Garb-aging'.炎症与“垃圾-衰老”。
COVID-19 介导的肝损伤中的年龄依赖性免疫反应：聚焦细胞因子。
Front Endocrinol (Lausanne). 2023 Aug 15;14:1139692. doi: 10.3389/fendo.2023.1139692. eCollection 2023.
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The effect of the mindfulness-based interventions on inflammaging: Protocol for a systematic review and meta-analysis.基于正念的干预对炎症衰老的影响：系统评价和荟萃分析方案。
PLoS One. 2023 Apr 7;18(4):e0284228. doi: 10.1371/journal.pone.0284228. eCollection 2023.
5
cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging.cGAS-STING 通路作为免疫衰老和炎症衰老的潜在触发因素。
Front Immunol. 2023 Feb 28;14:1132653. doi: 10.3389/fimmu.2023.1132653. eCollection 2023.
6
Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis.肥胖会引发肿瘤衰老，并使免疫原性差的恶性肿瘤易于发生衰老细胞溶解。
Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2209973120. doi: 10.1073/pnas.2209973120. Epub 2022 Dec 27.
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Trends Endocrinol Metab. 2017 Mar;28(3):199-212. doi: 10.1016/j.tem.2016.09.005. Epub 2016 Oct 24.
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Aging (Albany NY). 2016 Jul;8(7):1294-315. doi: 10.18632/aging.100991.
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Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.运动可预防饮食诱导的脂肪组织细胞衰老。
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Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.慢性炎症（炎症衰老）及其对与年龄相关疾病的潜在贡献。
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