Guangdong Provincial Institute of Public Health, Guangzhou, China.
Public Health. 2013 Jul;127(7):607-13. doi: 10.1016/j.puhe.2013.04.008. Epub 2013 Jun 14.
Inconsistent findings of association between supplemental folate consumption and pancreatic cancer risk have been observed in the literature. This study aims to summarize the relationship between folate intake and risk of pancreatic cancer.
Pertinent studies published before November 2011 were identified by searching PubMed and Embase and by reviewing the reference lists of retrieved articles. The summary relative risks were estimated by the random effects model. A linear regression analysis of the natural logarithm of the relative risk (RR) was carried out to assess a possible dose-response relationship between folate intake and pancreatic cancer risk.
Ten studies on dietary and supplemental folate intake and pancreatic cancer (4 case-control and 6 cohort studies) were included in the meta-analysis. The pooled RRs of pancreatic cancer for the highest vs lowest categories of dietary folate intake and supplemental folate intake were 0.66 (95% CI: 0.49-0.88) and 1.08 (95% CI, 0.82-1.41), respectively. The dose-response meta-analysis indicated that a 100 μg/day increment in dietary folate intake conferred a RR of 0.93 (95% CI: 0.90-0.97). These findings support the hypothesis that dietary folate may play a protective role in carcinogenesis of pancreatic cancer.
文献中观察到补充叶酸摄入与胰腺癌风险之间的关联存在不一致的结果。本研究旨在总结叶酸摄入与胰腺癌风险之间的关系。
通过搜索 PubMed 和 Embase 以及查阅检索到的文章的参考文献，确定了 2011 年 11 月之前发表的相关研究。通过随机效应模型估计汇总相对风险。对相对风险（RR）的自然对数进行线性回归分析，以评估叶酸摄入与胰腺癌风险之间可能存在的剂量-反应关系。
10 项关于饮食和补充叶酸摄入与胰腺癌（4 项病例对照研究和 6 项队列研究）的研究被纳入荟萃分析。饮食叶酸摄入和补充叶酸摄入最高与最低类别之间胰腺癌的汇总 RR 分别为 0.66（95%CI：0.49-0.88）和 1.08（95%CI，0.82-1.41）。剂量-反应荟萃分析表明，饮食叶酸摄入增加 100μg/天，RR 为 0.93（95%CI：0.90-0.97）。这些发现支持了饮食叶酸可能在胰腺癌发生过程中发挥保护作用的假设。
