早期人类发育的新见解：对干细胞的诱导分化的启示。
New Insights into Early Human Development: Lessons for Stem Cell Derivation and Differentiation.
机构信息
Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children and Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 0A4, Canada.
Embryology Unit, Children's Medical Research Institute and School of Medical Sciences, Sydney Medical School, University of Sydney, Westmead, NSW 2145, Australia.
出版信息
Cell Stem Cell. 2017 Jan 5;20(1):18-28. doi: 10.1016/j.stem.2016.12.004.
Pathways underlying mouse embryonic development have always informed efforts to derive, maintain, and drive differentiation of human pluripotent stem cells. However, direct application of mouse embryology to the human system has not always been successful because of fundamental developmental differences between species. The naive pluripotent state of mouse embryonic stem cells (ESCs), in particular, has been difficult to capture in human ESCs, and appears to be transitory in the human embryo itself. Further studies of human and non-human primate embryo development are needed to untangle the complexities of pluripotency networks across mammalian species.
在将人类多能干细胞进行诱导、维持和分化的过程中，小鼠胚胎发育的相关途径一直是研究的重点。然而，由于物种间存在根本的发育差异，将小鼠胚胎学直接应用于人类系统并不总是成功。特别是，小鼠胚胎干细胞（ESCs）的原始多能状态一直难以在人类 ESCs 中获得，并且在人类胚胎本身中似乎是短暂的。需要进一步研究人类和非人类灵长类动物的胚胎发育，以理清跨哺乳动物物种的多能性网络的复杂性。
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