Di Carlo Marco, Lato Valentina, Di Matteo Andrea, Carotti Marina, Salaffi Fausto
Rheumatology Department, Clinica Reumatologica, Polytechnic University of the Marche, c/o Ospedale "Carlo Urbani", Via Aldo Moro, 25, 60035, Jesi, AN, Italy.
Radiology Department, Polytechnic University of the Marche, Ancona, Italy.
Rheumatol Int. 2017 May;37(5):713-718. doi: 10.1007/s00296-016-3642-9. Epub 2017 Jan 6.
The Assessment of SpondyloArthritis international Society Health Index (ASAS HI) is an inclusive questionnaire, able to describe the total impairments and restrictions due to axial spondyloarthritis (axSpA). Considering the relationship between ASAS HI and the Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP, the aim of this study is to establish the ASAS HI cut-off values for functioning categories employing the ASDAS-CRP disease activity states in axSpA patients. ASAS HI and ASDAS-CPR were obtained from 140 consecutive axSpA patients, divided in the four ASDAS-CRP disease activity categories. High and very high disease activity were considered together. The ASAS HI cut-offs were obtained from the arithmetic mean, rounded off to the closest whole number, of the 75th percentile mean value of a lower rank and the 25th percentile mean value of the adjacent higher rank. This approach was applied in the transition from inactive disease and moderate disease activity, and in the transition from moderate disease activity and high/very high disease activity. Twenty-three patients were classified as having inactive disease, 36 were classified as having moderate disease activity, and 81 were in a high/very high disease activity state. Using the approach of the 75th-25th percentile mean values of adjacent disease activity states, the ASAS HI cut-offs resulted: ≤4 to dinstinguish a normal functioning, >4 and ≤8 to distinguish a moderate impairment of functioning, and >8 to distinguish a severe impairment of functioning. ASAS HI seems a reliable tool to define functioning categories in patients with axSpA.
脊柱关节炎国际协会健康指数（ASAS HI）是一份综合性问卷，能够描述轴性脊柱关节炎（axSpA）所致的整体损伤和限制。考虑到ASAS HI与强直性脊柱炎疾病活动评分（ASDAS）-CRP之间的关系，本研究旨在确定axSpA患者中根据ASDAS-CRP疾病活动状态划分功能类别的ASAS HI临界值。从140例连续的axSpA患者中获取ASAS HI和ASDAS-CPR，这些患者被分为四个ASDAS-CRP疾病活动类别。将高疾病活动度和非常高疾病活动度合并考虑。ASAS HI临界值是通过较低等级第75百分位数平均值与相邻较高等级第25百分位数平均值的算术平均值得到的，四舍五入到最接近的整数。这种方法应用于从不活动疾病到中度疾病活动的转变，以及从中度疾病活动到高/非常高疾病活动的转变。23例患者被分类为患有不活动疾病，36例被分类为患有中度疾病活动，81例处于高/非常高疾病活动状态。采用相邻疾病活动状态第75 - 25百分位数平均值的方法，得到的ASAS HI临界值如下：≤4表示功能正常，>4且≤8表示功能有中度损伤，>8表示功能有严重损伤。ASAS HI似乎是定义axSpA患者功能类别的可靠工具。
