Pentikäinen Heikki, Ngandu Tiia, Liu Yawu, Savonen Kai, Komulainen Pirjo, Hallikainen Merja, Kivipelto Miia, Rauramaa Rainer, Soininen Hilkka
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
Age Ageing. 2017 Mar 1;46(2):310-313. doi: 10.1093/ageing/afw191.
high cardiorespiratory fitness (CRF) is associated with larger brain volumes but data on sex differences in the association of CRF with brain volumes are scarce. We investigated whether the association of CRF with total grey matter (GM) and white matter volumes as well as medial temporal lobe and striatum volumes is different between men and women at increased risk for Alzheimer's disease (AD).
we used baseline data from The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) in which the inclusion criteria were set to select individuals with cognitive performance at the mean level or slightly lower than expected for age according to Finnish population norms. Our sub-study included 39 randomly selected men and 29 women aged 61-75 years. CRF was assessed as peak oxygen consumption (VO2peak) measured in a maximal exercise test on cycle ergometer. Brain structural imaging was performed using a 1.5-T scanner.
in men, VO2peak was associated with cortical GM volume (β = 0.56, P = 0.001) and total GM volume (β = 0.54, P = 0.001). In women, no associations were found between VO2peak and brain volumes. VO2peak accounted for 23% and 1% of total variance of cortical GM volume as well as 25% and 4% of total variance of total GM volume in men and women, respectively.
CRF is associated with cortical GM and total GM volumes in elderly men at increased risk for AD, but not in women.
高心肺适能（CRF）与更大的脑容量相关，但关于CRF与脑容量关联中的性别差异数据稀缺。我们调查了在患阿尔茨海默病（AD）风险增加的男性和女性中，CRF与总灰质（GM）、白质体积以及内侧颞叶和纹状体体积之间的关联是否存在差异。
我们使用了芬兰老年干预预防认知障碍和残疾研究（FINGER）的基线数据，该研究的纳入标准是根据芬兰人群规范选择认知表现处于平均水平或略低于预期年龄水平的个体。我们的子研究包括39名随机选择的61 - 75岁男性和29名女性。CRF通过在自行车测力计上进行的最大运动测试中测量的峰值耗氧量（VO2peak）来评估。使用1.5-T扫描仪进行脑结构成像。
在男性中，VO2peak与皮质GM体积（β = 0.56，P = 0.001）和总GM体积（β = 0.54，P = 0.001）相关。在女性中，未发现VO2peak与脑容量之间存在关联。VO2peak分别占男性和女性皮质GM体积总方差的23%和1%，以及总GM体积总方差的25%和4%。
在患AD风险增加的老年男性中，CRF与皮质GM和总GM体积相关，但在女性中并非如此。
