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使用简短健康调查问卷36比较脊髓型颈椎病与其他慢性衰弱性疾病的生活质量。

Comparing Quality of Life in Cervical Spondylotic Myelopathy with Other Chronic Debilitating Diseases Using the Short Form Survey 36-Health Survey.

作者信息

Oh Taemin, Lafage Renaud, Lafage Virginie, Protopsaltis Themistocles, Challier Vincent, Shaffrey Christopher, Kim Han Jo, Arnold Paul, Chapman Jens, Schwab Frank, Massicotte Eric, Yoon Tim, Bess Shay, Fehlings Michael, Smith Justin, Ames Christopher

机构信息

Department of Neurological Surgery, UCSF, San Francisco, California, USA.

Hospital for Special Surgery, Department of Orthopaedic Surgery, New York, New York, USA.

出版信息

World Neurosurg. 2017 Oct;106:699-706. doi: 10.1016/j.wneu.2016.12.124. Epub 2017 Jan 5.

Abstract

BACKGROUND

Although cervical spondylotic myelopathy (CSM) can be devastating, its relative impact on general health remains unclear. Patient responses to the Short Form Survey 36-Health Survey (SF-36) Physical Component Summary (PCS)/Mental Component Summary (MCS) were compared between CSM and other diseases to evaluate their respective impacts on quality of life. The objective of this study was to compare SF-36 PCS/MCS scores in CSM with population and disease-specific norms.

METHODS

Retrospective analysis of a prospective, multicenter AOSpine North American CSM Study database. Inclusion criteria were symptomatic disease, age older than 18 years, cord compression on magnetic resonance imaging or computed tomography myelography, and baseline SF-36 values. SF-36 PCS/MCS scores in CSM were compared with national normative values and disease-specific norms using Student t test. Analysis of variance was used to assess differences across age groups and offsets from age-matched controls. Threshold for significance was P < 0.05.

RESULTS

There were 285 patients who met the inclusion criteria. The mean age was 56.6 ± 12.0 years, with male predominance (60%). SF-36 scores revealed significant baseline disability (PCS: 34.5 ± 9.8; MCS: 41.5 ± 14.4). Although there were no differences across age groups, when compared with age-matched normative data, younger patients had a larger PCS offset than older patients. CSM caused worse physical disability than most diseases except heart failure. Only back pain/sciatica induced worse mental disability.

CONCLUSIONS

CSM affects quality of life to an extent greater than diabetes or cancer. Although mean impact of CSM does not vary with age, younger patients suffer from greater differences in baseline function. This study highlights the impact of myelopathy on patient function, particularly among younger age groups, and suggests that CSM merits a similar caliber of healthy policy attention as more well-studied diseases.

摘要

背景

尽管脊髓型颈椎病(CSM)可能具有破坏性,但其对总体健康的相对影响仍不明确。比较了CSM患者与其他疾病患者对简明健康状况调查简表36(SF - 36)身体成分总结(PCS)/心理成分总结(MCS)的反应,以评估它们对生活质量的各自影响。本研究的目的是将CSM患者的SF - 36 PCS/MCS评分与总体人群及疾病特异性标准进行比较。

方法

对一项前瞻性、多中心北美脊柱协会(AOSpine)CSM研究数据库进行回顾性分析。纳入标准为有症状的疾病、年龄大于18岁、磁共振成像或计算机断层扫描脊髓造影显示脊髓受压以及SF - 36的基线值。使用学生t检验将CSM患者的SF - 36 PCS/MCS评分与全国标准值和疾病特异性标准进行比较。采用方差分析评估不同年龄组之间的差异以及与年龄匹配对照组的偏差。显著性阈值为P < 0.05。

结果

有285例患者符合纳入标准。平均年龄为56.6 ± 12.0岁,男性占主导(60%)。SF - 36评分显示出显著的基线残疾(PCS:34.5 ± 9.8;MCS:41.5 ± 14.4)。尽管各年龄组之间没有差异,但与年龄匹配的标准数据相比,年轻患者的PCS偏差比老年患者更大。除心力衰竭外,CSM导致的身体残疾比大多数疾病更严重。只有背痛/坐骨神经痛导致更严重的心理残疾。

结论

CSM对生活质量的影响程度大于糖尿病或癌症。尽管CSM的平均影响不随年龄变化,但年轻患者在基线功能方面的差异更大。本研究强调了脊髓病对患者功能的影响,特别是在年轻年龄组中,并表明CSM应得到与研究更充分的疾病类似程度的健康政策关注。

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