Najib Nashwa, Yataganbaba Alper, Briggs Nancy E, Ghahreman Ali, Mobbs Ralph, Rao Prashant J, Hansen Mitchell, Davies Mark, Kohan Saeed, Kulkarni Vinay, Sial Alisha, Ambikaipalan Anuruthran, Diwan Ashish D
University of New South Wales (UNSW), Sydney, Australia.
Royal Melbourne Hospital, Melbourne, Australia.
ANZ J Surg. 2025 May;95(5):979-984. doi: 10.1111/ans.19354. Epub 2024 Dec 17.
Degenerative Cervical Myelopathy (DCM) is the most common cause of non-traumatic, chronic spinal cord dysfunction worldwide, causing debilitating disability with a diminishing quality of life. The natural history of DCM is poorly understood. This is a preliminary report of the first 60 patients recruited to the MYelopathy NAtural History (MYNAH) Registry.
MYNAH Registry is an investigator-initiated, multicenter, prospective, non-interventional, longitudinal, national observational study (Registry ID ACSQHC-ARCR-258). Given the observational nature of the Registry, participants' clinical management plan is neither changed nor affected. Participants are recruited via an opt-in approach. A patient with DCM diagnosed by a spine/neurosurgeon after 1st January 2018 onwards is eligible to participate regardless of their surgical status. The Patient-Reported Outcome Measures (PROMs) are NDI, EQ5D5L and EQ-VAS; and the Practitioner-Reported Outcome Measures (PrROMs) are mJOA Score and Nurick Grade.
Sixty participants (n = 60) have now been recruited of which male participants 34 (56.7%) and females are 26 (43.3%), with a mean age of 62.3 years (SD 14.1) and biospecimens for Proteomics have been collected from 33 (66%) participants. The median mJOA Score was 16.5 (8-18), with myelopathy severity recorded as mild in 42 (70%), moderate in 13 (21.7%) and severe in 5 (8.3%) participants. Median Nurick Grade 0 (0-5), NDI 14 (0-45), EQ5D5L Score 0.850 (-0.288-1) and EQ-VAS 70 (10-96).
The MYNAH National DCM Registry in Australia is a novel spinal surgical initiative, that will inform the decision(s) to proceed with the scientific, evidence-based and personalised management of DCM globally in the future.
退行性颈椎脊髓病（DCM）是全球非创伤性慢性脊髓功能障碍的最常见原因，导致使人衰弱的残疾，生活质量不断下降。人们对DCM的自然病史了解甚少。这是一份关于入选脊髓病自然病史（MYNAH）登记处的首批60例患者的初步报告。
MYNAH登记处是一项由研究者发起的、多中心、前瞻性、非干预性、纵向的全国性观察性研究（登记号ACSQHC-ARCR-258）。鉴于该登记处的观察性质，参与者的临床管理计划既不会改变也不会受到影响。参与者通过选择加入的方式招募。2018年1月1日之后由脊柱/神经外科医生诊断为DCM的患者，无论其手术状态如何，均有资格参与。患者报告的结局指标（PROMs）为颈部功能障碍指数（NDI）、EQ5D5L和EQ视觉模拟量表（EQ-VAS）；医生报告的结局指标（PrROMs）为改良日本骨科学会（mJOA）评分和努里克分级。
现已招募60名参与者（n = 60），其中男性参与者34名（56.7%），女性26名（43.3%），平均年龄62.3岁（标准差14.1），已从33名（66%）参与者中收集了用于蛋白质组学研究的生物样本。mJOA评分中位数为16.5（8 - 18），42名（70%）参与者的脊髓病严重程度记录为轻度，13名（21.7%）为中度，5名（8.3%）为重度。努里克分级中位数为0（0 - 5），NDI为14（0 - 45），EQ5D5L评分为0.850（-0.288 - 1），EQ-VAS为70（10 - 96）。
澳大利亚的MYNAH全国DCM登记处是一项新颖的脊柱外科倡议，它将为未来全球范围内对DCM进行科学、循证和个性化管理的决策提供依据。
