Sopelak V M, Whitworth N S, Norman P F, Cowan B D
University of Mississippi Medical Center, Jackson.
Fertil Steril. 1989 Oct;52(4):627-32. doi: 10.1016/s0015-0282(16)60976-7.
Thirty-two patients undergoing in vitro fertilization (IVF) were given bromocriptine either 1 or 12 hours before anesthesia or received no drug to determine what effect suppression of transient, anesthesia-induced hyperprolactinemia would have on peripheral and follicular fluid hormones, fertilization and cleavage rates, and pregnancy. Thirty minutes after anesthesia, there was a 120-ng/mL rise in serum prolactin (PRL) in control patients versus an insignificant change in women given bromocriptine. Levels of PRL in follicular fluid were significantly less, and estradiol (E2) levels were higher (P less than 0.05) in all bromocriptine-treated patients compared with controls, whereas follicular fluid levels of progesterone (P), inhibin activity, and midluteal serum P were unaffected. Although fertilization and pregnancy rates were similar, a greater proportion of fertilized oocytes from bromocriptine-treated patients advanced to cleaving embryos compared with controls (95% versus 63%, respectively; P less than 0.001). We conclude that bromocriptine, given before anesthesia, can suppress transient, anesthesia-induced hyperprolactinemia and dramatically alter follicular fluid concentrations of PRL and E2. Although these changes in hormonal milieu affected neither oocyte fertilization nor pregnancy rate in our IVF patients, they seemed to have a positive influence on embryonic development after IVF.
32名接受体外受精（IVF）的患者在麻醉前1小时或12小时给予溴隐亭，或不使用药物，以确定抑制短暂性麻醉诱导的高催乳素血症对外周血和卵泡液激素、受精率和卵裂率以及妊娠的影响。麻醉后30分钟，对照组患者血清催乳素（PRL）升高120 ng/mL，而给予溴隐亭的女性变化不显著。与对照组相比，所有接受溴隐亭治疗的患者卵泡液中的PRL水平显著降低，雌二醇（E2）水平升高（P<0.05），而卵泡液中的孕酮（P）水平、抑制素活性和黄体中期血清P不受影响。尽管受精率和妊娠率相似，但与对照组相比，接受溴隐亭治疗的患者中发育为分裂期胚胎的受精卵比例更高（分别为95%和63%；P<0.001）。我们得出结论，麻醉前给予溴隐亭可抑制短暂性麻醉诱导的高催乳素血症，并显著改变卵泡液中PRL和E2的浓度。尽管这些激素环境的变化对我们IVF患者的卵母细胞受精和妊娠率均无影响，但它们似乎对IVF后的胚胎发育有积极影响。
