Reinthaller A, Bieglmayer C, Deutinger J, Csaicsich P
Second Department of Obstetrics and Gynecology, University of Vienna Medical School, Austria.
Fertil Steril. 1988 Mar;49(3):432-6. doi: 10.1016/s0015-0282(16)59768-4.
The effect of transient hyperprolactinemia and its treatment during cycle stimulation on the endocrine response and fertilization rate of human oocytes was studied. Fifty stimulated cycles were included in the study and divided into three groups: group I consisted of 18 cycles with serum prolactin (PRL) levels less than or equal to 25 ng/ml; group II contained 15 cycles, where patients developed PRL levels greater than 25 ng/ml; group III consisted of 17 cycles, where patients, who already developed hyperprolactinemia in a previous cycle, were treated by 3.75 mg bromocriptine daily. The serum estradiol (E2), progesterone (P) and PRL levels 1, 2, and 3 days before and at oocyte retrieval were evaluated. The E2 decrease at oocyte retrieval was significantly steeper in groups I and III. Follicular luteinization was more effective in groups I and III. The fertilization rate in groups I and III was significantly higher than in group II. High serum PRL levels seem to interfere in follicular and oocyte development. The treatment of transient hyperprolactinemia improved the patients' endocrine response and the fertilization rate of oocytes.
研究了周期刺激期间短暂性高泌乳素血症及其治疗对人卵母细胞内分泌反应和受精率的影响。该研究纳入了50个刺激周期，并将其分为三组：第一组由18个血清泌乳素（PRL）水平小于或等于25 ng/ml的周期组成；第二组包含15个周期，这些患者的PRL水平高于25 ng/ml；第三组由17个周期组成，这些患者在前一个周期已出现高泌乳素血症，每天接受3.75 mg溴隐亭治疗。评估了取卵前1、2和3天以及取卵时的血清雌二醇（E2）、孕酮（P）和PRL水平。第一组和第三组在取卵时E2下降明显更陡。第一组和第三组的卵泡黄素化更有效。第一组和第三组的受精率显著高于第二组。高血清PRL水平似乎会干扰卵泡和卵母细胞的发育。短暂性高泌乳素血症的治疗改善了患者的内分泌反应和卵母细胞的受精率。
