血小板活化因子对人类精子运动能力的影响。
The effects of platelet-activating factor on the motility of human spermatozoa.
作者信息
Ricker D D, Minhas B S, Kumar R, Robertson J L, Dodson M G
机构信息
Department of Obstetrics and Gynecology, East Tennessee State University, James H. Quillen College of Medicine, Johnson City 37614.
出版信息
Fertil Steril. 1989 Oct;52(4):655-8. doi: 10.1016/s0015-0282(16)60981-0.
Our laboratory has recently detected the presence of platelet-activating factor (PAF)-like activity in human spermatozoa. To gain further insight into the role of PAF on the male reproductive system, this study, using videomicroscopy, evaluated the effects of synthetic PAF on the motility of human spermatozoa. Treatment of 20 human semen samples with 3.69 x 10(-7) to 3.69 x 10(-13) M PAF resulted in statistically significant increases in motility. Treatment of spermatozoa with lyso-PAF (the biologically inactive form of PAF) showed no change in motility. Treatment of spermatozoa with PAF in severely asthenozoospermic males may be of therapeutic value.
我们实验室最近检测到人类精子中存在血小板活化因子（PAF）样活性。为了进一步深入了解PAF在男性生殖系统中的作用，本研究使用视频显微镜评估了合成PAF对人类精子活力的影响。用3.69×10⁻⁷至3.69×10⁻¹³ M的PAF处理20份人类精液样本后，精子活力出现了具有统计学意义的显著增加。用溶血PAF（PAF的无生物活性形式）处理精子后，活力没有变化。用PAF治疗严重弱精子症男性的精子可能具有治疗价值。
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