Taylor W Robert, Iffrig Elizabeth, Veneziani Alessandro, Oshinski John N, Smolensky Alexander
ATLANTA, GEORGIA.
Trans Am Clin Climatol Assoc. 2016;127:148-161.
The prevalence of abdominal aortic aneurysms differs greatly between men and women across the spectrum of ages. The reason for this discrepancy is not clear and likely involves several factors including the impact of sex hormones. We hypothesize that the unique spatial localization of abdominal aortic aneurysms is dictated in part by local hemodynamic forces on the vascular wall. Specifically, we propose that oscillatory shear stress is a specific signal to the endothelium that initiates the events ultimately leading to abdominal aortic aneurysm formation. We are proposing that sex-dependent differences in oscillatory shear stress in the infra-renal aorta may explain the observed differences between men and women. Initial observations suggest that, indeed, men and women have different degrees of oscillatory blood flow in the infra-renal abdominal aorta. The challenge is to extend these observations to show a causal relationship between oscillatory flow and aneurysm formation.
在各个年龄段，腹主动脉瘤的患病率在男性和女性之间存在很大差异。这种差异的原因尚不清楚，可能涉及多种因素，包括性激素的影响。我们假设腹主动脉瘤独特的空间定位部分是由血管壁上的局部血流动力学力决定的。具体而言，我们提出振荡剪切应力是一种向内皮细胞发出的特定信号，它启动了最终导致腹主动脉瘤形成的一系列事件。我们认为，肾下腹主动脉中振荡剪切应力的性别差异可能解释了观察到的男性和女性之间的差异。初步观察表明，实际上，男性和女性肾下腹主动脉中的振荡血流程度不同。挑战在于扩展这些观察结果，以显示振荡血流与动脉瘤形成之间的因果关系。
