Rogovskii Vladimir Stanislavovich
Department of Molecular Pharmacology and Radiobiology, Pirogov Russian National Research Medical University, Bolshaya Pirogovskaya st. 9a, Moscow, 119435, Russian Federation.
Curr Cancer Drug Targets. 2017;17(4):325-332. doi: 10.2174/1568009617666170109110816.
It is widely accepted that chronic inflammation critically contributes to cancer. Immune tolerance in cancer mediates tumor escape from the immune system. The mechanisms of relations between inflammation and immune tolerance are still not fully elucidated.
The main mechanisms that link inflammation and tolerance are considered. Drug targets that are in use to interfere with inflammation in cancer are discussed.
Inflammation mediates tumor-induced tolerance. The induction and the maintenance of the chronic inflammatory response is a universal mechanism of immune tolerance.
慢性炎症对癌症的发生发展起着关键作用，这一观点已被广泛接受。癌症中的免疫耐受介导肿瘤逃避免疫系统。炎症与免疫耐受之间的关系机制仍未完全阐明。
探讨炎症与耐受之间的主要联系机制。讨论目前用于干预癌症炎症的药物靶点。
炎症介导肿瘤诱导的耐受。慢性炎症反应的诱导和维持是免疫耐受的普遍机制。
