Abd-Elghany Amr A, Ahmed Samya Mahmoud, Masoud Marwa A, Atia Tarek, Waggiallah Hisham Ali, El-Sakhawy Mohamed A, Mohamad Ebtesam A
Radiology and Medical Imaging Department, College of Applied Medical Sciences, Prince Sattam Bin Abdul-Aziz University, Al-Kharj11942, Saudi Arabia.
Biophysics Department, Faculty of Science, Cairo University, Giza12613, Egypt.
ACS Omega. 2022 Oct 21;7(43):38436-38447. doi: 10.1021/acsomega.2c03649. eCollection 2022 Nov 1.
Current research is focused on cancer treatments other than chemotherapy medications, particularly those derived from natural sources. The goal of this work was to look at the anticancer and biomarker properties of a methanolic extract of leaves and their extract-loaded noisome. leaves extract and their leaves extract-loaded noisome were prepared. Transmission electron microscopy was used to screen the size of the niosomes loaded with the L. leaves extract. The tumor size, blood picture (hemoglobin, red blood cells, white blood cells), liver functions, kidney function, oxidative stress, and inflammatory markers were evaluated to assess the potential anticancer activity of the leaves extract and leaves extract-loaded noisome in Ehrlich ascites carcinoma. L. leaves extract was found to be an effective anticancer treatment. The protective effect of the loaded extract showed more significant results. All treated groups showed a lower tumor volume compared to the positive control. Liver and kidney functions were improved, and inflammatory markers were decreased. Oxidative stress was improved in tumor, liver, and kidney tissues. leaves contain major anticancer compounds that in general help most enzymes of the liver and kidney and other injured organs to return to their normal levels.
当前的研究集中在化疗药物以外的癌症治疗方法上，特别是那些源自天然来源的方法。这项工作的目标是研究树叶甲醇提取物及其负载提取物的泡囊的抗癌和生物标志物特性。制备了树叶提取物及其负载树叶提取物的泡囊。使用透射电子显微镜筛选负载树叶提取物的泡囊的大小。评估肿瘤大小、血液指标（血红蛋白、红细胞、白细胞）、肝功能、肾功能、氧化应激和炎症标志物，以评估树叶提取物和负载树叶提取物的泡囊在艾氏腹水癌中的潜在抗癌活性。发现树叶提取物是一种有效的抗癌治疗方法。负载提取物的保护作用显示出更显著的结果。与阳性对照相比，所有治疗组的肿瘤体积均较小。肝功能和肾功能得到改善，炎症标志物减少。肿瘤、肝脏和肾脏组织中的氧化应激得到改善。树叶含有主要的抗癌化合物，总体上有助于肝脏、肾脏和其他受损器官的大多数酶恢复到正常水平。
