Department of Chemical and Biological Engineering, Koc University, Sariyer, Istanbul, Turkey.
Department of Molecular Biology and Genetics, Koc University, Sariyer, Istanbul, Turkey.
Photochem Photobiol. 2017 Jan;93(1):93-103. doi: 10.1111/php.12669. Epub 2017 Jan 9.
Light is a very important environmental factor that governs many cellular responses in organisms. As a consequence, organisms possess different kinds of light-sensing photoreceptors to regulate their physiological variables and adapt to a given habitat. The cryptochrome/photolyase family (CPF) includes photoreceptors that perform different functions in different organisms. Photolyases repair ultraviolet-induced DNA damage by a process known as photoreactivation using photons absorbed from the blue end of the light spectrum. On the other hand, cryptochromes act as blue light circadian photoreceptors in plants and Drosophila to regulate growth and development. In mammals, cryptochromes have light-independent functions and are very important transcriptional regulators that act at the molecular level as negative transcriptional regulators of the circadian clock. In this review, we highlight current knowledge concerning the structural and functional relationships of CPF members.
光是一种非常重要的环境因素，它控制着生物体的许多细胞反应。因此，生物体拥有不同种类的光感受器来调节它们的生理变量并适应特定的栖息地。隐花色素/光解酶家族（CPF）包括在不同生物体中执行不同功能的光感受器。光解酶通过利用从光光谱的蓝色末端吸收的光子进行光复活过程来修复紫外线诱导的 DNA 损伤。另一方面，隐花色素在植物和果蝇中作为蓝光生物钟光感受器，调节生长和发育。在哺乳动物中，隐花色素具有非光依赖性功能，是非常重要的转录调节剂，作为生物钟的负转录调节剂在分子水平上发挥作用。在这篇综述中，我们强调了关于 CPF 成员的结构和功能关系的现有知识。
