Karimian Pegah, Yaghini Omid, Nasr Azadani Hossein, Mohammadizadeh Majid, Arabzadeh Seyed Ali Mohammad, Adibi Atosa, Rahimi Hamid
Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Medical Virology, Tehran University of Medical Sciences, Tehran, Iran.
Interdiscip Perspect Infect Dis. 2016;2016:7812106. doi: 10.1155/2016/7812106. Epub 2016 Dec 14.
Need of neonatal screening for (CMV) infection is under debate, in part because of limited data on importance of the disease regarding the prevalence of congenital CMV (cCMV) infection and associated morbidity and mortality. We aimed to evaluate the prevalence and prognosis of cCMV infection in Iran, where there is high maternal seroprevalence of CMV. . This prospective study was conducted in Isfahan city, Iran, from 2014 to 2016. CMV was investigated in urine specimens by using the real-time polymerase chain reaction (RT-PCR) method. CMV-infected infants were examined for clinical and laboratory findings attributed to CMV infection and followed up for one year. Among 1617 studied neonates, eight (0.49%) were positive for CMV infection. CMV-infected neonates were more likely to be preterm than noninfected ones (25% versus 4.5%, = 0.0508), and they had lower birth weight. Three out of the eight CMV-infected neonates had transient symptoms at birth. At follow-up, one case had mild hearing loss. Most patients had impaired growth during the one-year follow-up. The primary object of this study was determination of prevalence of cCMV infection in Iran as a developing country, which was at the lower range compared with other such countries. cCMV infection may result in short-term impairment in growth.
新生儿巨细胞病毒（CMV）感染筛查的必要性仍存在争议，部分原因是关于先天性CMV（cCMV）感染的患病率以及相关发病率和死亡率，该疾病重要性的数据有限。我们旨在评估伊朗cCMV感染的患病率和预后情况，伊朗孕妇CMV血清阳性率较高。这项前瞻性研究于2014年至2016年在伊朗伊斯法罕市进行。通过实时聚合酶链反应（RT-PCR）方法对尿液标本进行CMV检测。对CMV感染的婴儿进行CMV感染相关临床和实验室检查结果的检查，并随访一年。在1617名研究的新生儿中，8名（0.49%）CMV感染呈阳性。CMV感染的新生儿比未感染的新生儿更易早产（25%对4.5%，P = 0.0508），且出生体重较低。8名CMV感染的新生儿中有3名在出生时出现短暂症状。随访时，有1例出现轻度听力损失。大多数患者在一年随访期间生长发育受损。本研究的主要目的是确定作为发展中国家的伊朗cCMV感染的患病率，与其他此类国家相比处于较低水平。cCMV感染可能导致生长短期受损。
