二氧化硫前药：通过点击反应触发二氧化硫的释放。
Sulfur dioxide prodrugs: triggered release of SOvia a click reaction.
作者信息
Wang Wenyi, Ji Xingyue, Du Zhenming, Wang Binghe
机构信息
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30303, USA.
出版信息
Chem Commun (Camb). 2017 Jan 24;53(8):1370-1373. doi: 10.1039/c6cc08844a.
Abstract
Sulfur dioxide (SO) is being recognized as a possible endogenous gasotransmitter with importance on par with that of NO, CO, and HS. Herein we describe a series of SO prodrugs that are activated for SO release via a bioorthogonal click reaction. The release rate can be tuned by adjusting the substituents on the prodrug.
摘要
二氧化硫（SO）正被认为是一种可能的内源性气体递质，其重要性与一氧化氮（NO）、一氧化碳（CO）和硫化氢（HS）相当。在此，我们描述了一系列通过生物正交点击反应被激活以释放SO的前药。释放速率可通过调整前药上的取代基来调节。
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