Wang Wenyi, Ji Xingyue, Du Zhenming, Wang Binghe
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30303, USA.
Chem Commun (Camb). 2017 Jan 24;53(8):1370-1373. doi: 10.1039/c6cc08844a.
Sulfur dioxide (SO) is being recognized as a possible endogenous gasotransmitter with importance on par with that of NO, CO, and HS. Herein we describe a series of SO prodrugs that are activated for SO release via a bioorthogonal click reaction. The release rate can be tuned by adjusting the substituents on the prodrug.
二氧化硫（SO）正被认为是一种可能的内源性气体递质，其重要性与一氧化氮（NO）、一氧化碳（CO）和硫化氢（HS）相当。在此，我们描述了一系列通过生物正交点击反应被激活以释放SO的前药。释放速率可通过调整前药上的取代基来调节。
